Chemokine Signaling in Chemotherapy-Induced Neuropathic Pain

• Published in: International journal of molecular sciences Vol. 20; no. 12; p. 2904
• Main Authors: Brandolini, Laura, d'Angelo, Michele, Antonosante, Andrea, Allegretti, Marcello, Cimini, Annamaria
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.06.2019; MDPI
• Subjects: Antioxidants; Apoptosis; Biomolecules; Breast cancer; Calcium channels; Calcium ions; Carbonyl compounds; Carbonyls; Cell cycle; central nervous system; Channels; Chemokines; Chemotherapy; Cytokines; Cytotoxicity; Demyelination; Deoxyribonucleic acid; DNA; DNA damage; Drug dosages; Endoplasmic reticulum; Immune system; Inflammation; inflammatory mediators; Kinases; Lymphocytes; Microtubules; Mitochondrial DNA; Natural killer cells; Nervous system; Neurotoxicity; Nociceptors; Oxaliplatin; Oxidative stress; Paclitaxel; Pain; Pain perception; Paresthesia; Peripheral blood; peripheral nervous system; Peripheral neuropathy; Phospholipids; Proteins; Review; Sodium channels; Taxanes; Transient receptor potential proteins; Tumor necrosis factor-TNF; Vincristine; inflammatory mediators; cytokines; peripheral nervous system; chemokines; chemotherapy; central nervous system
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20122904

Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of chemotherapics such as taxanes, vinca alkaloids, and platinum compounds. In recent years, several reports have indicated the involvement of different molecular mechanisms in CIPN. The pathways described so far are diverse and target various components of the peripheral Nervous System (PNS). Among the contributors to neuropathic pain, inflammation has been indicated as a powerful driver of CIPN. Several pieces of evidence have demonstrated a chemotherapy-induced increase in peripheral pro-inflammatory cytokines and a strong correlation with peripheral neuropathy. At present, there are not adequate strategies to prevent CIPN, although there are drugs for treating CIPN, such as duloxetine, that have displayed a moderate effect on CIPN. In this review, we focus on the players involved in CIPN with a particular emphasis on chemokine signaling.