A Sweet Origin for the Key Congocidine Precursor 4-Acetamidopyrrole-2-carboxylate
Feeding (Streptomyces) frenzy: Natural products belonging to the pyrrolamide family are defined by their pyrrole‐2‐carboxamide moiety. 4‐acetamidopyrrole‐2‐carboxylate is identified as the key pyrrolamide congocidine precursor (see scheme) through feeding studies using Streptomyces ambofaciens. The...
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Published in | Angewandte Chemie (International ed.) Vol. 51; no. 30; pp. 7454 - 7458 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
23.07.2012
WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc Wiley-VCH Verlag |
Edition | International ed. in English |
Subjects | |
Online Access | Get full text |
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Summary: | Feeding (Streptomyces) frenzy: Natural products belonging to the pyrrolamide family are defined by their pyrrole‐2‐carboxamide moiety. 4‐acetamidopyrrole‐2‐carboxylate is identified as the key pyrrolamide congocidine precursor (see scheme) through feeding studies using Streptomyces ambofaciens. The biosynthetic pathway of congocidine starts with the carbohydrate N‐acetylglucosamine and involves carbohydrate‐processing enzymes. |
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Bibliography: | Pôle de Recherche et d'Enseignement Supérieur UniverSud Paris European Union - No. CT-2004-0005224; No. CT-2005-029154 ArticleID:ANIE201201445 We would like to thank Dr. Christophe Corre for helpful discussions, Dr. Laurent Micouin for his help with the synthesis of the 4-acetamidopyrrole-2-methanol, and Dr. Cyrille Kouklovsky, Géraldine Le Goff, and Dr. Robert Thaï for their help with mass spectrometry. This work was supported in part by the European Union through the Integrated Project ActinoGEN (CT-2004-0005224) and the reintegration grant BOPA (CT-2005-029154), by the Pôle de Recherche et d'Enseignement Supérieur UniverSud Paris and by the Bettencourt Schueller Foundation. Bettencourt Schueller Foundation ark:/67375/WNG-T7VD2GKK-N istex:32AB189D044B2BCA1E4B724A31E05BB7DDA556DF We would like to thank Dr. Christophe Corre for helpful discussions, Dr. Laurent Micouin for his help with the synthesis of the 4‐acetamidopyrrole‐2‐methanol, and Dr. Cyrille Kouklovsky, Géraldine Le Goff, and Dr. Robert Thaï for their help with mass spectrometry. This work was supported in part by the European Union through the Integrated Project ActinoGEN (CT‐2004‐0005224) and the reintegration grant BOPA (CT‐2005‐029154), by the Pôle de Recherche et d’Enseignement Supérieur UniverSud Paris and by the Bettencourt Schueller Foundation. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.201201445 |