Dynamics of HIV‐1 replication following influenza vaccination of HIV+ individuals

• Published in: Clinical and experimental immunology Vol. 104; no. 2; pp. 203 - 207
• Main Authors: RØSOK, B., VOLTERSVIK, P., BJERKNES, R., AXELSSON, M., HAAHEIM, L. R., ÅSJÖ, B.
• Format: Journal Article
• Language: English
• Published: Oxford BSL Blackwell Science Ltd 01.05.1996; Blackwell; Blackwell Science Inc
• Subjects: AIDS/HIV; Biological and medical sciences; CD4-Positive T-Lymphocytes - virology; haemagglutination inhibition; Hemagglutinins - biosynthesis; HIV; HIV Seropositivity - immunology; HIV Seropositivity - virology; HIV-1 - immunology; HIV-1 - physiology; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; influenza; Influenza Vaccines - adverse effects; Influenza Vaccines - immunology; Lymphocyte Activation; Medical sciences; Medicin och hälsovetenskap; Review; vaccination; viral load; Virus Replication - immunology; Human; Immunopathology; Seropositivity; HIV-1 virus; Viremia; Vaccination; Retroviridae; Orthomyxoviridae; AIDS; Immune deficiency; Influenzavirus; Host virus relation; Infection; Virus; Viral disease; Risk factor; Lentivirinae; Replication; Human immunodeficiency virus
• ISSN: 0009-9104; 1365-2249
• DOI: 10.1046/j.1365-2249.1996.25732.x

Levels of HIV‐1 have been reported to increase in peripheral blood after influenza vaccination of HIV+ individuals. In this study we have evaluated the dynamics of these changes. Ten HIV‐1+ individuals classified in revised CDC clinical categories B and C as well as five seronegative healthy controls were vaccinated with the recommended influenza strains. HIV viral RNA and proviral DNA were sequentially quantified in serum and blood lymphocytes, respectively. Nine of the 10 HIV+ individuals had an increase in the frequency of infected CD4 cells 2 weeks after influenza vaccination. Individuals with low viral load had a rapid increase in viraemia and a small increase in frequency of infected cells in peripheral blood. In contrast, individuals with high viral load had a small drop in viraemia followed by a significant rise in the rate of infected cells. The observed changes may resemble those taking place during intercurrent infections in HIV+ individuals. The effects of the relative increases in infectious virus after the transient viraemic phase should be further investigated to evaluate potential risks of vaccination.