A Highly Tunable Biocompatible and Multifunctional Biodegradable Elastomer

• Published in: Advanced materials (Weinheim) Vol. 25; no. 8; pp. 1209 - 1215
• Main Authors: Pereira, Maria José Nunes, Ouyang, Ben, Sundback, Cathryn A., Lang, Nora, Friehs, Ingeborg, Mureli, Shwetha, Pomerantseva, Irina, McFadden, Jacob, Mochel, Mark C., Mwizerwa, Olive, del Nido, Pedro, Sarkar, Debanjan, Masiakos, Peter T., Langer, Robert, Ferreira, Lino S., Karp, Jeffrey M.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 25.02.2013; WILEY‐VCH Verlag
• Subjects: Animals; Biocompatibility; biocompatible materials; Biocompatible Materials - chemistry; Biocompatible Materials - toxicity; Biodegradability; biodegradable polymers; biomacromolecules; Biomaterials; Biomedical materials; Decanoates - chemistry; Decanoates - metabolism; Decanoates - toxicity; drug delivery; Elastomers; Elastomers - chemistry; Encapsulation; Glycerol - analogs & derivatives; Glycerol - chemistry; Glycerol - metabolism; Glycerol - toxicity; Humans; Lactic Acid - chemistry; Lactic Acid - metabolism; Lactic Acid - toxicity; Mechanical properties; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - drug effects; Polyglycolic Acid - chemistry; Polyglycolic Acid - metabolism; Polyglycolic Acid - toxicity; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers - chemistry; Polymers - metabolism; Polymers - toxicity; Surgical implants; Tissue Engineering
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.201203824

Biodegradable elastomers synthesized under mild conditions with highly tunable mechanical properties are described. These elastomeric biomaterials are biocompatible, exhibit minimal deformation following cyclical tensile loading, and permit tight control over the release kinetics of encapsulated bioactive molecules.