Idiopathic dilated cardiomyopathy in dogs: survival and prognostic indicators

• Published in: Journal of veterinary internal medicine Vol. 9; no. 1; pp. 12 - 17
• Main Authors: Monnet, E. (Colorado State University, Fort Collins, CO.), Orton, E.C, Salman, M, Boon, J
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.1995
• Subjects: Animals; CARDIOMYOPATHIE; CARDIOMYOPATHY; Cardiomyopathy, Dilated - diagnosis; Cardiomyopathy, Dilated - mortality; Cardiomyopathy, Dilated - veterinary; CHIEN; DEATH; DIGOXIN; Dog Diseases - diagnosis; Dog Diseases - mortality; DOGS; DRUGS; EDEMA; ESTEROIDES; FUROSEMIDE; LUNGS; Male; MEDICAMENT; MEDICAMENTOS; MIOCARDIOPATIA; MORT; MUERTE; OEDEMA; OEDEME; PATHOGENESE; PATHOGENESIS; PATOGENESIS; PERRO; PLEURA; Pleural Effusion - mortality; Pleural Effusion - veterinary; PLEVRE; POUMON; PROGNOSIS; PULMONES; Retrospective Studies; STEROIDE; STEROIDS; SUPERVIVENCIA; SURVIE; SURVIVAL; Survival Rate; Ventricular Dysfunction, Left - mortality; Ventricular Dysfunction, Left - veterinary; Weight Loss
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/j.1939-1676.1995.tb03266.x

To further define the prognosis and identify clinical findings predictive for survival in dogs with dilated cardiomyopathy (DCM), we performed Kaplan Meier survival analysis of 37 dogs with idiopathic DCM. Survival analysis showed that the 50% probability of survival occurred at 2.3 months. Probability of survival at 1 year was 37.5% and at 2 years was 28%. Bivariate Cox proportional hazard ratios identified pleural effusion and pulmonary edema, both signs of congestive heart failure, as independent prognostic indicators for dogs with DCM (P < .01). Hazard ratios for these prognostic indicators were 2.354 and 3.291, respectively. Multivariate Cox stepwise regression identified pleural effusion, left ventricular free‐wall thickening fraction, ventricular ectopy, and weight loss as significant prognostic indicators for dogs with DCM. Because of the retrospective nature of this study, the effects of different drug treatments were not evaluated. The type of cardiac‐related death, progressive failure versus sudden death, was not addressed in this study and requires further evaluation.