Aging by epigenetics—A consequence of chromatin damage?

Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-de...

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Bibliographic Details
Published inExperimental cell research Vol. 314; no. 9; pp. 1909 - 1917
Main Authors Sedivy, John M., Banumathy, Gowrishankar, Adams, Peter D.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 10.06.2008
Elsevier BV
Subjects
60 APPLIED LIFE SCIENCES
AGING
Aging - genetics
Animals
Cancer
Cell senescence
Cellular biology
CHROMATIN
Chromatin - genetics
Chromatin - pathology
Chromatin Assembly and Disassembly
DNA DAMAGES
Epigenesis, Genetic
Epigenetics
Humans
Life expectancy
Longevity
NEOPLASMS
Progeria - pathology
STOCHASTIC PROCESSES
Yeasts - physiology
Epigenetics
Aging
Chromatin
Cell senescence
Longevity
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Summary:Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.
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ISSN:0014-4827
1090-2422
1090-2422
DOI:10.1016/j.yexcr.2008.02.023