Optimizing bone morphogenic protein 4-mediated human embryonic stem cell differentiation into trophoblast-like cells using fibroblast growth factor 2 and transforming growth factor-β/activin/nodal signalling inhibition

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Bibliographic Details
Published inReproductive biomedicine online Vol. 35; no. 3; pp. 253 - 263
Main Authors Koel, Mariann, Võsa, Urmo, Krjutškov, Kaarel, Einarsdottir, Elisabet, Kere, Juha, Tapanainen, Juha, Katayama, Shintaro, Ingerpuu, Sulev, Jaks, Viljar, Stenman, Ulf-Hakan, Lundin, Karolina, Tuuri, Timo, Salumets, Andres
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.09.2017
Subjects
Activins - genetics
Activins - metabolism
Bone Morphogenetic Protein 4 - pharmacology
bone morphogenic protein 4
Cell Culture Techniques - methods
Cell Differentiation - drug effects
Cell Differentiation - genetics
Cells, Cultured
Down-Regulation - drug effects
Down-Regulation - genetics
fibroblast growth factor 2
Fibroblast Growth Factor 2 - genetics
Fibroblast Growth Factor 2 - metabolism
human embryonic stem cell
Human Embryonic Stem Cells - drug effects
Human Embryonic Stem Cells - physiology
Humans
Medicin och hälsovetenskap
Nodal Protein - genetics
Nodal Protein - metabolism
Obstetrics and Gynecology
placenta
Signal Transduction - drug effects
Signal Transduction - genetics
Transforming Growth Factor beta - genetics
Transforming Growth Factor beta - metabolism
transforming growth factor-β
trophoblast cells
Trophoblasts - drug effects
Trophoblasts - physiology
placenta
bone morphogenic protein 4
human embryonic stem cell
trophoblast cells
transforming growth factor-β
fibroblast growth factor 2
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ISSN:1472-6483
1472-6491
1472-6491
DOI:10.1016/j.rbmo.2017.06.003