Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

• Published in: Evidence-Based Complementary and Alternative Medicine Vol. 2022; pp. 1 - 10
• Main Authors: Islam, Fahadul, Mitra, Saikat, Nafady, Mohamed H., Rahman, Mohammad Tauhidur, Tirth, Vineet, Akter, Aklima, Emran, Talha Bin, Mohamed, Amany Abdel-Rahman, Algahtani, Ali, El-Kholy, Sanad S.
• Format: Journal Article
• Language: English
• Published: United States Hindawi 28.03.2022; Hindawi Limited; John Wiley & Sons, Inc
• Subjects: Animal models; Animals; Antidepressants; Antidiabetics; Anxiety; Body weight; Diabetes; Diabetes mellitus; Exploratory behavior; Flavonoids; Hyperglycemia; Kinases; Mental depression; Mental disorders; Oxidative stress; Phytochemicals; Psychotropic drugs; Research Article; Sleep; Sodium; Steroids; Thiopental; Wound healing; Bangladesh
• ISSN: 1741-427X; 1741-4288
• DOI: 10.1155/2022/6144733

The present study examines the neuropharmacological and antidiabetic properties of methanol leaves extract of Lannea coromandelica in animal models. This study is carried out by elevated plus-maze apparatus, motor coordination, thiopental sodium has an induction role in sleeping time, hole board, hole cross, open field, antidiabetic studies. Mice were treated doses of 100, 150, and 200 mg/kg body weight in elevated plus-maze apparatus and motor coordination; 100 and 200 mg/kg body weight in sleeping time, hole cross, hole board, and open field tests; and 200 and 400 mg/kg body weight in the antidiabetic activity test. Extraction specifies a significantly decreased time duration and sleeping time in a thiopental sodium-induced sleeping time test. The experimental extract decreased locomotor and exploratory behaviors of mice in the open-field and hole-cross tests compared to the effects of the control. Furthermore, the extract increased sleeping time with a dose-dependent onset of action. The hole-board test extract also demonstrated a reduced number of head dips. The findings showed that L. coromandelica has potential neuropharmacological effects. In addition, in alloxan-induced diabetic mice, leaves extract at 200 and 400 mg/kg body weight revealed significant antidiabetic properties and could be used to manage blood glucose levels with more research.