The MYCN Protein in Health and Disease

is a member of the family of proto-oncogenes. It encodes a transcription factor, MYCN, involved in the control of fundamental processes during embryonal development. The MYCN protein is situated downstream of several signaling pathways promoting cell growth, proliferation and metabolism of progenito...

Full description

Saved in:
Bibliographic Details
Published inGenes Vol. 8; no. 4; p. 113
Main Authors Ruiz-Pérez, María Victoria, Henley, Aine Brigette, Arsenian-Henriksson, Marie
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 30.03.2017
MDPI
Subjects
Medicin och hälsovetenskap
Review
neuroblastoma
targeted therapy
childhood tumors
MYCN
embryonal development
Online AccessGet full text

Cover

More Information
Summary:is a member of the family of proto-oncogenes. It encodes a transcription factor, MYCN, involved in the control of fundamental processes during embryonal development. The MYCN protein is situated downstream of several signaling pathways promoting cell growth, proliferation and metabolism of progenitor cells in different developing organs and tissues. Conversely, deregulated MYCN signaling supports the development of several different tumors, mainly with a childhood onset, including neuroblastoma, medulloblastoma, rhabdomyosarcoma and Wilms' tumor, but it is also associated with some cancers occurring during adulthood such as prostate and lung cancer. In neuroblastoma, -amplification is the most consistent genetic aberration associated with poor prognosis and treatment failure. Targeting MYCN has been proposed as a therapeutic strategy for the treatment of these tumors and great efforts have allowed the development of direct and indirect MYCN inhibitors with potential clinical use.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2073-4425
2073-4425
DOI:10.3390/genes8040113