Gene polymorphisms of adiponectin and leptin receptor are associated with early onset of type 2 diabetes mellitus in the Taiwanese population

• Published in: International Journal of Obesity Vol. 36; no. 6; pp. 790 - 796
• Main Authors: Liao, W-L, Chen, C-C, Chang, C-T, Wu, J-Y, Chen, C-H, Huang, Y-C, Tsai, C-H, Tsai, F-J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2012; Nature Publishing Group
• Subjects: Adiponectin - blood; Adult; Age; Age of Onset; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Blood; Blood Glucose - metabolism; Body fat; C-Reactive Protein - metabolism; Cardiovascular disease; Cholesterol - blood; Cross-Sectional Studies; Deoxyribonucleic acid; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Diabetes. Impaired glucose tolerance; DNA; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Epidemiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fatty acids; Fatty Acids - blood; Female; Genes; Genetic aspects; Genetic Predisposition to Disease; Genotype; Genotypes; Glucose; Glycated Hemoglobin A - metabolism; Health Promotion and Disease Prevention; Hormone receptors; Hospitals; Humans; Insulin resistance; Internal Medicine; Male; Medical research; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Middle Aged; Obesity; original-article; Oxidation; Patients; Pediatrics; Physiological aspects; Polymorphism; Polymorphism, Single Nucleotide; Public Health; Receptors, Leptin - blood; Risk factors; Serology; Single nucleotide polymorphisms; Taiwan - epidemiology; Type 2 diabetes; Young adults; Asia; Taiwan; China; adiponectin; polymorphism; type 2 diabetes; early-onset; leptin receptor; Taiwan; Endocrinopathy; Type 2 diabetes; Obesity; Nutrition; Nutrition disorder; Metabolic diseases; Adipokine; Adiponectin; Association; Leptin; Population; Early; Nutritional status; Polymorphism
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/ijo.2011.174

Objective: Adipocytokine genes encoding adiponectin (ADIPOQ) and the leptin receptor ( LEPR ) affect glucose and fatty acid metabolism. The purpose of this study was to examine the association between early-onset type 2 diabetes mellitus (T2DM) and variability within these two genes in the Han Chinese population of Taiwan. Subjects: A cross-sectional study of 999 patients from the Han Chinese population of Taiwan with early-onset T2DM ( n =264; age at diagnosis, 20 to <45 years) and late-onset T2DM ( n =735; age at diagnosis, ⩾45 years) was performed. Blood samples from T2DM patients were taken for DNA extraction, and levels of serological markers were measured at enrollment. Seven single-nucleotide polymorphisms (SNPs) were selected for genotyping (three SNPs in AIDPOQ and four SNPs in LEPR ) by polymerase chain reaction in each patient. Results: Polymorphisms at the position rs10937273 in ADIPOQ and at the positions rs1892534 and rs2211651 in LEPR were statistically associated with early-onset T2DM ( P =0.0246, 0.0014 and 0.0012, respectively). C-reactive protein levels were significantly different among the early-onset T2DM patients with different genotypes at the SNPs rs1892534 and rs2211651 in LEPR ( P =0.003 and P =0.004, respectively). In addition, fasting glucose levels were also significantly different among different genotypes at the SNP rs1892534 in LEPR ( P =0.038). Conclusion: We conclude that the polymorphisms in the adipocytokine genes ADIPOQ and LEPR are significantly associated with the age at diagnosis of T2DM in the Han Chinese population of Taiwan.