Gas Flow and Ion Transfer in Heated ESI Capillary Interfaces

Transfer capillaries are the preferred means to transport ions, generated by electrospray ionization, from ambient conditions to vacuum. During the transfer of ions through the narrow, long tubes into vacuum, substantial losses are typical. However, recently it was demonstrated that these losses can...

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Bibliographic Details
Published inJournal of the American Society for Mass Spectrometry Vol. 29; no. 4; pp. 761 - 773
Main Authors Bernier, Laurent, Pinfold, Harry, Pauly, Matthias, Rauschenbach, Stephan, Reiss, Julius
Format Journal Article
LanguageEnglish
Published New York Springer US 01.04.2018
Springer Nature B.V
American Chemical Society
Subjects
Analytical Chemistry
Bioinformatics
Biotechnology
CAPILLARIES
Chemical Sciences
Chemistry
Chemistry and Materials Science
COMPARATIVE EVALUATIONS
Computer simulation
COMPUTERIZED SIMULATION
DIFFUSION
Gas dynamics
GAS FLOW
HEATING
INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
Ion transport
IONIZATION
IONS
Mass spectrometry
Mathematical models
or physical chemistry
Organic Chemistry
Proteomics
Research Article
SPACE CHARGE
Theoretical and
Tubes
Gasflow
Simulation
Atmospheric pressure interfaces
Transfer
ESI
Transport capillary
High transfer
Gasdynamic
Design principles
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Summary:Transfer capillaries are the preferred means to transport ions, generated by electrospray ionization, from ambient conditions to vacuum. During the transfer of ions through the narrow, long tubes into vacuum, substantial losses are typical. However, recently it was demonstrated that these losses can be avoided altogether. To understand the experimental observation and provide a general model for the ion transport, here, we investigate the ion transport through capillaries by numerical simulation of interacting ions. The simulation encompasses all relevant factors, such as space charge, diffusion, gas flow, and heating. Special attention is paid to the influence of the gas flow on the transmission and especially the change imposed by heating. The gas flow is modeled by a one-dimensional gas dynamics description. A large number of ions are treated as point particles in this gas flow. This allows to investigate the influence of the capillary heating on the gas flow and by this on the ion transport. The results are compared with experimental findings. Graphical Abstract ᅟ
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ISSN:1044-0305
1879-1123
DOI:10.1007/s13361-018-1895-0