Testosterone, obesity, and waist circumference as determinants of metabolic syndrome in Saudi women

• Published in: Diabetes, metabolic syndrome and obesity Vol. 11; pp. 175 - 181
• Main Authors: Fatani, Sameer H, Abdelbasit, Nazik Altayeb, Al-Amodi, Hiba S, Mukhtar, Maowia Mohamed, Babakr, Abdullatif Taha
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2018; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Analysis; Cardiovascular diseases; Care and treatment; Cholesterol; Complications and side effects; Consultants (Persons); EDTA; Enzyme-linked immunosorbent assay; Enzymes; Glucose; Health risk assessment; Hyperlipidemia; Insulin; Insulin resistance; Low density lipoproteins; Medical research; Metabolic diseases; Metabolic Syndrome; Obesity; Original Research; Risk factors; Testosterone; Triglycerides; Type 2 diabetes; Women; Women's health; Womens health; Saudi Arabia; metabolic syndrome; androgen; hyperlipidemia; testosterone; lipid profile; insulin resistance; obesity
• ISSN: 1178-7007; 1178-7007
• DOI: 10.2147/DMSO.S156021

High serum total testosterone is associated with metabolic syndrome (MS). This study aimed to identify possible alterations in total testosterone and their relationship with plasma glucose, blood pressure, and serum lipid profile. One hundred forty-two female subjects were selected to participate in this study, and they were recruited by consultant physicians from the Clinic and Medical Out-Patient, King Abdulaziz Hospital, Kingdom of Saudi Arabia. The anthropometric characteristics were obtained from questionnaires by using standard methods. Blood samples were obtained for the determination of glucose, triglycerides, total cholesterol, low-density lipoprotein, and high-density lipoprotein by using enzymatic methods. Total testosterone was determined by enzyme-linked immunosorbent assay for the quantitative measurement of testosterone in human serum. Significantly higher concentrations of total testosterone, low-density lipoprotein, and glucose, but lower concentrations of high-density lipoprotein, were observed in subjects with MS compared with women without MS ( <0.05). This study suggests that high levels of total testosterone and disturbance in lipid profile were associated with MS in Saudi women.