Antibacterial Effects of Grape Extracts on Helicobacter pylori

• Published in: Applied and Environmental Microbiology Vol. 75; no. 3; pp. 848 - 852
• Main Authors: Brown, Joseph C, Huang, Guohui, Haley-Zitlin, Vivian, Jiang, Xiuping
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.02.2009; American Society for Microbiology (ASM)
• Subjects: Agar; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; antibacterial properties; Bacteria; Berries; Biological and medical sciences; cell proliferation; Cells; confocal laser scanning microscopy; Fruits; Fundamental and applied biological sciences. Psychology; grapes; Helicobacter pylori; Helicobacter pylori - drug effects; Helicobacter pylori - growth & development; Microbial Sensitivity Tests; Microbiology; Microscopy, Confocal; Phenols; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Public Health Microbiology; Seeds; Vitis - chemistry; Spirillales; Helicobacter pylori; Grape; Spirillaceae; Bacteria; Extract; Antibacterial agent
• ISSN: 0099-2240; 1098-5336; 1098-5336; 1098-6596
• DOI: 10.1128/AEM.01595-08

Anti-Helicobacter pylori activities were determined by agar dilution, confocal laser scanning microscopy, and cell proliferation assays following treatment with various grape extracts. Muscadine grape skin possessed the strongest activity, followed by grape synergy (skin and seed) and seed, suggesting that higher phenolic levels do not necessarily determine overall anti-H. pylori efficacy.