Lymphocyte-to-Monocyte Ratio and Clinical Outcomes in Cholangiocarcinoma: A Systematic Review and Meta-Analysis

• Published in: Diagnostics (Basel) Vol. 12; no. 11; p. 2655
• Main Authors: Dotto-Vasquez, Giuseppe, Villacorta-Ampuero, Andrea K, Ulloque-Badaracco, Juan R, Hernandez-Bustamante, Enrique A, Alarcón-Braga, Esteban A, Herrera-Añazco, Percy, Benites-Zapata, Vicente A, Hernandez, Adrian V
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2022; MDPI
• Subjects: Bias; Bile ducts; Cholangiocarcinoma; Clinical outcomes; Cohort analysis; Health aspects; Liver cancer; Lymphocytes; lymphocyte–monocyte ratio; Medical prognosis; Meta-analysis; Monocytes; Peer review; survival; Systematic Review; Tumors; Peru; South Korea
• ISSN: 2075-4418; 2075-4418
• DOI: 10.3390/diagnostics12112655

Lymphocyte-to-Monocyte ratio (LMR) has shown an association with survival outcomes in several oncological diseases. This study aimed to evaluate the association between LMR and clinical outcomes for cholangiocarcinoma patients. A systematic review and meta-analysis were performed to assess the association between LMR values and overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) and time to recurrence (TTR) in cholangiocarcinoma patients. We used Hazard ratio (HR) and their 95% confidence interval (CI) as a measure of effect for the random effect model meta-analysis. The Newcastle–Ottawa Scale was used for quality assessment. The Egger test and funnel plot were developed for approaching publication bias. A total of 19 studies were included in this study (n = 3860). The meta-analysis showed that cholangiocarcinoma patients with low values of LMR were associated with worse OS (HR: 0.82; 95% CI: 0.71–0.96; I2 = 86%) and worse TTR (HR: 0.71; 95% CI: 0.58–0.86; I2 = 0%). DFS and RFS also were evaluated; however, they did not show statistically significant associations. Low LMR values were associated with a worse OS and TTR.