THE CHEMICAL REPAIR REACTION OF THYMINE AND THYMIDINE DIOL DERIVATIVES, MODELS OF OXIDATIVELY DAMAGED NUCLEIC ACIDS, BY TRIVALENT PHOSPHORUS COMPOUNDS

When treated with trivalent phosphorus compounds, thymine and thymidine diol derivatives, models of oxidatively damaged nucleic acids, were reductively repaired to regenerate the original thymine and thymidine derivatives. A possible mechanism is proposed.

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 39; no. 5; pp. 1333 - 1334
Main Authors YANADA, Reiko, BESSHO, Kiyoshi, HARAYAMA, Takashi, YONEDA, Fumio
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1991
Maruzen
Subjects
1, 3-dimethylthymine diol
Carbohydrates. Nucleosides and nucleotides
Chemistry
damaged nucleic acid model
Exact sciences and technology
mechanism
Nucleosides, nucleotides and oligonucleotides
Organic chemistry
phosphine
phosphite
Preparations and properties
reduction
repair reaction
thymidine diol derivative
Chemical modification
Model compound
Deoxyribonucleoside
Repair
Pyrimidine nucleoside
Phosphorus Organic compounds
Nucleic acid
Glycol
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Summary:When treated with trivalent phosphorus compounds, thymine and thymidine diol derivatives, models of oxidatively damaged nucleic acids, were reductively repaired to regenerate the original thymine and thymidine derivatives. A possible mechanism is proposed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.39.1333