Dual mechanism of protection by live attenuated Bordetella pertussis BPZE1 against Bordetella bronchiseptica in mice

• Published in: Vaccine Vol. 30; no. 40; pp. 5864 - 5870
• Main Authors: Kammoun, Hana, Feunou, Pascal Feunou, Foligne, Benoit, Debrie, Anne-Sophie, Raze, Dominique, Mielcarek, Nathalie, Locht, Camille
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 31.08.2012
• Subjects: Administration, Intranasal; Adoptive Transfer; Allergy and Immunology; Animals; Antibodies; Antibodies, Bacterial - blood; antigens; Bacterial Load; Bordetella bronchiseptica; Bordetella bronchiseptica - immunology; Bordetella Infections - immunology; Bordetella Infections - prevention & control; Bordetella parapertussis; Bordetella pertussis; Bordetella pertussis - immunology; CD25 antigen; CD4 antigen; Chronic infection; Clinical trials; Cytokines - immunology; Female; Foxp3 protein; Gram-negative bacteria; Helper cells; hosts; humans; Immunity, Cellular; Immunization - methods; Immunoregulation; Inflammation; Intranasal administration; Leukocytes (neutrophilic); Lung; Lung - immunology; lungs; Lymphocytes B; Lymphocytes T; Mice; Mice, Inbred BALB C; Mice, SCID; neutrophils; Pertussis; Pertussis Vaccine - immunology; pneumonia; Pneumonia - immunology; Pneumonia - microbiology; recruitment; Regulatory T cells; Respiratory tract diseases; T-lymphocytes; T-Lymphocytes, Regulatory - immunology; Th1 Cells - immunology; Th17 Cells - immunology; Vaccine; Vaccines; Vaccines, Attenuated - immunology; Bordetella bronchiseptica; Vaccine; Bordetella pertussis; Regulatory T cells
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2012.07.005

Highlights ► Live attenuated B. pertussis BPZE1 protects against B. bronchiseptica . ► BPZE1-induced protection is due to a dual cell-mediated immune mechanism. ► Both effector cells and regulatory T cells participate in protection.