Synthetic Antibacterial Quaternary Phosphorus Salts Promote Methicillin-Resistant Staphylococcus aureus -Infected Wound Healing

• Published in: International journal of nanomedicine Vol. 18; pp. 1145 - 1158
• Main Authors: Shi, Liang-Wen, Zhuang, Quan-Quan, Wang, Tai-Qin, Jiang, Xian-Dong, Liu, Yue, Deng, Jing-Wen, Sun, Huan-Huan, Li, Yi, Li, Hao-Hong, Liu, Ting-Bo, Liu, Jian-Zhi
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2023; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; antibacterial; Antibiotics; Antimicrobial agents; Bacteria; Bacterial infections; biocompatible; Biofilms; Drug resistance; Drug resistance in microorganisms; Gold; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Morphology; Nanoparticles; Original Research; Peptides; Phosphorus; Proteins; quaternary phosphorus salts; Rats; reactive oxygen species; Salts - pharmacology; Scanning electron microscopy; Sodium Chloride - pharmacology; Staphylococcus aureus; Staphylococcus aureus infections; Staphylococcus infections; Titanium alloys; Toxicity; World health; Wound Healing; wound infection therapy; China; biocompatible; antibacterial; quaternary phosphorus salts; wound infection therapy; reactive oxygen species
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/IJN.S398748

Drug-resistant microbes pose a global health concern, requiring the urgent development of effective antibacterial agents and strategies in clinical practice. Therefore, there is an urgent need to explore novel antibacterial materials to effectively eliminate bacteria. The synthesis of quaternary phosphonium salt in haloargentate systems, wherein the phosphorus atom is represented in a cationic form, is a possible strategy for the development of antibacterial materials. Using (triphenyl)phosphonium-based quaternary phosphorus salts with different spacer lengths (n=2, 4, 6) as a template, we designed three kinds of quaternary phosphorus salts as effective antibacterial agents against drug-resistant bacteria. The synthesized quaternary phosphorus salt of (1,4-DBTPP)Br effectively prevented the formation of the bacterial biofilms, and degraded bacterial membranes and cell walls by promoting the production of reactive oxygen species, which exhibited effective therapeutic effects in a rat model of a superficial wound infected with methicillin-resistant . The quaternary phosphorus salt (1,4-DBTPP)Br demonstrated hemocompatibility and low toxicity, revealing its potential in the treatment of clinical infections.