Are Local Drug Delivery Systems a Challenge in Clinical Periodontology?

• Published in: Journal of clinical medicine Vol. 12; no. 12; p. 4137
• Main Authors: Budală, Dana Gabriela, Luchian, Ionut, Tatarciuc, Monica, Butnaru, Oana, Armencia, Adina Oana, Virvescu, Dragoș Ioan, Scutariu, Monica Mihaela, Rusu, Darian
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.06.2023; MDPI
• Subjects: Anti-infective agents; Antibiotics; Bacteria; Biofilms; Chemokines; Clinical medicine; Cytokines; Dental research; Disease; Dosage and administration; Drug administration; drug delivery system; Drug delivery systems; Drug resistance; Drug therapy; Drugs; Gum disease; Hydrogels; Medical research; Nanoparticles; oral diseases; periodontal disease; Periodontitis; Polymers; Review; Transplants & implants; Vehicles; Romania; oral diseases; hydrogels; nanoparticles; drug delivery system; periodontal disease
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12124137

Placing antimicrobial treatments directly in periodontal pockets is an example of the local administration of antimicrobial drugs to treat periodontitis. This method of therapy is advantageous since the drug concentration after application far surpasses the minimum inhibitory concentration (MIC) and lasts for a number of weeks. As a result, numerous local drug delivery systems (LDDSs) utilizing various antibiotics or antiseptics have been created. There is constant effort to develop novel formulations for the localized administration of periodontitis treatments, some of which have failed to show any efficacy while others show promise. Thus, future research should focus on the way LDDSs can be personalized in order to optimize future clinical protocols in periodontal therapy.