Teratoma-negative anti-NMDA receptor encephalitis presenting with a single generalized tonic–clonic seizure

• Published in: Epilepsy & behavior case reports Vol. 10; pp. 29 - 31
• Main Authors: Ng, Andy Cheuk-Him, Tripic, Miljan, Mirsattari, Seyed M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2018; Elsevier
• Subjects: Anti-NMDA encephalitis; Autoimmune; Neurology; Psychiatric symptoms; Seizure; magnetic resonance imaging; MRI; EEG; cerebral spinal fluid; Anti-NMDA encephalitis; Intravenous immunoglobulin; IVIg; anti-NMDA; HSV; F/U; electroencephalogram; GTC(S); generalized tonic–clonic (seizure); follow up; herpes simplex virus; CT; CSF; anti- N-methyl- d-aspartate; Autoimmune; Seizure; computerized tomography; Psychiatric symptoms; PCR; polymerase chain reaction; EEG, electroencephalogram; CSF, cerebral spinal fluid; anti-NMDA, anti-N-methyl-d-aspartate; IVIg, Intravenous immunoglobulin; MRI, magnetic resonance imaging; HSV, herpes simplex virus; CT, computerized tomography; GTC(S), generalized tonic–clonic (seizure); PCR, polymerase chain reaction; F/U, follow up
• ISSN: 2213-3232; 2213-3232
• DOI: 10.1016/j.ebcr.2018.02.001

Abstract Herein, we describe a case report of anti-NMDA receptor encephalitis characterized by a single generalized tonic–clonic seizure and predominantly psychiatric symptoms, persisting long after EEG abnormalities had resolved. We discuss common presentations of anti-NMDA receptor encephalitis and advocate for the inclusion of this disease entity in the differential diagnosis of patients presenting with one generalized tonic–clonic seizure and prominent psychiatric symptoms.