DSigDB: drug signatures database for gene set analysis

• Published in: Bioinformatics Vol. 31; no. 18; pp. 3069 - 3071
• Main Authors: Yoo, Minjae, Shin, Jimin, Kim, Jihye, Ryall, Karen A., Lee, Kyubum, Lee, Sunwon, Jeon, Minji, Kang, Jaewoo, Tan, Aik Choon
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 15.09.2015
• Subjects: Applications Notes; Bioinformatics; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Computational Biology - methods; Computer programs; Databases, Pharmaceutical; Drug Repositioning; Drugs; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Genes; Humans; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Mutation - genetics; Protein Kinase Inhibitors - pharmacology; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Receptor, Epidermal Growth Factor - genetics; Signatures; Software
• ISSN: 1367-4803; 1367-4811; 1367-4811; 1460-2059
• DOI: 10.1093/bioinformatics/btv313

We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research. Availability and implementation: DSigDB is freely available for non-commercial use at http://tanlab.ucdenver.edu/DSigDB. Supplementary information:  Supplementary data are available at Bioinformatics online. Contact:  aikchoon.tan@ucdenver.edu