Interleukin-10 promoter single-nucleotide polymorphisms as markers for disease susceptibility and disease severity in leprosy

We have determined IL-10 promoter genotypes of five single-nucleotide polymorphisms (SNPs): T-3575A, A-2849G, C-2763A, -A-1082G and C-819T. The haplotype frequencies were defined in healthy subjects compared to leprosy patients, and analyzed for their occurrence in multi- (MB) vs paucibacillary (PB)...

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Published inGenes and immunity Vol. 5; no. 7; pp. 592 - 595
Main Authors Moraes, M O, Pacheco, A G, Schonkeren, J J M, Vanderborght, P R, Nery, J A C, Santos, A R, Moraes, M E, Moraes, J R, Ottenhoff, T H M, Sampaio, E P, Huizinga, T W J, Sarno, E N
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.11.2004
Subjects
Confidence Intervals
Female
Gene Frequency - genetics
Genetic aspects
Genetic Markers - genetics
Genetic Predisposition to Disease
Haplotypes
Haplotypes - genetics
Health aspects
Humans
Interleukin 10
Interleukin-10 - genetics
Leprosy
Leprosy - genetics
Logistic Models
Male
Odds Ratio
Polymorphism, Single Nucleotide - genetics
Promoter Regions, Genetic - genetics
Risk factors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Brazil
Netherlands
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Summary:We have determined IL-10 promoter genotypes of five single-nucleotide polymorphisms (SNPs): T-3575A, A-2849G, C-2763A, -A-1082G and C-819T. The haplotype frequencies were defined in healthy subjects compared to leprosy patients, and analyzed for their occurrence in multi- (MB) vs paucibacillary (PB) as severe and mild forms of leprosy, respectively. Haplotypes defined by three SNP positions (-3575, -2849 and -2763) captured significant differences between controls and patients (P=0.04). The haplotype carrying -3575A, -2849G and -2763C was associated with resistance to leprosy and to the development of severe forms of the disease using either a binomial (controls vs cases, P=0.005, OR=0.35, CI=0.13-0.91) or ordinal (controls vs PB vs MB, P=0.006, OR=0.32, CI=0.12-0.83) model. By contrast, the IL-10 haplotype -3575T/-2849A/-2763C was found to be associated with susceptibility to leprosy per se (P=0.027, OR=2.37, CI=1.04-5.39), but not leprosy type. The data suggest that the IL-10 locus contributes to the outcome of leprosy.
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ISSN:1466-4879
1476-5470
DOI:10.1038/sj.gene.6364122