Regulation of NMDA receptors by phosphorylation

N-Methyl- d-aspartate (NMDA) receptors are critical for neuronal development and synaptic plasticity. The molecular mechanisms underlying the synaptic localization and functional regulation of NMDA receptors have been the subject of extensive studies. In particular, phosphorylation has emerged as a...

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Bibliographic Details
Published inNeuropharmacology Vol. 53; no. 3; pp. 362 - 368
Main Authors Chen, Bo-Shiun, Roche, Katherine W.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.2007
Subjects
Animals
Gene Expression - physiology
Glutamate
Kinase
NMDA receptors
Phosphorylation
Protein Transport - physiology
Receptors, N-Methyl-D-Aspartate - metabolism
Phosphorylation
NMDA receptors
Glutamate
Kinase
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Summary:N-Methyl- d-aspartate (NMDA) receptors are critical for neuronal development and synaptic plasticity. The molecular mechanisms underlying the synaptic localization and functional regulation of NMDA receptors have been the subject of extensive studies. In particular, phosphorylation has emerged as a fundamental mechanism that regulates NMDA receptor trafficking and can alter the channel properties of NMDA receptors. Here we summarize recent advances in the characterization of NMDA receptor phosphorylation, emphasizing subunit-specific phosphorylation, which differentially controls the trafficking and surface expression of NMDA receptors.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:0028-3908
1873-7064
DOI:10.1016/j.neuropharm.2007.05.018