Exposures, mechanisms, and impacts of endocrine-active flame retardants

Highlights • Widespread exposure to flame retardants occurs in indoor environments. • Indoor exposure is associated with body burdens. • Highest human exposures occur in early development, a sensitive window. • PBDEs elicit neurodevelopmental and thyroid hormone disrupting effects. • OPFRs also appe...

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Bibliographic Details
Published inCurrent opinion in pharmacology Vol. 19; pp. 125 - 133
Main Authors Dishaw, Laura V, J Macaulay, Laura, Roberts, Simon C, Stapleton, Heather M
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2014
Subjects
Animals
Endocrine Disruptors - toxicity
Environmental Exposure - adverse effects
Environmental Exposure - analysis
Flame Retardants - toxicity
Halogenated Diphenyl Ethers - toxicity
Humans
Internal Medicine
Medical Education
Organophosphates - toxicity
Organophosphorus Compounds - toxicity
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Summary:Highlights • Widespread exposure to flame retardants occurs in indoor environments. • Indoor exposure is associated with body burdens. • Highest human exposures occur in early development, a sensitive window. • PBDEs elicit neurodevelopmental and thyroid hormone disrupting effects. • OPFRs also appear to be endocrine active.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2014.09.018