TSPO Finds NOX2 in Microglia for Redox Homeostasis

During the past decade, translocator protein 18 kDa (TSPO), previously named peripheral benzodiazepine receptor, has gained a great deal of attention based on its use as a clinical biomarker of neuroinflammation with therapeutic potential. However, there is a paucity of knowledge on the function(s)...

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Bibliographic Details
Published inTrends in pharmacological sciences (Regular ed.) Vol. 37; no. 5; pp. 334 - 343
Main Authors Guilarte, Tomás R, Loth, Meredith K, Guariglia, Sara R
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.05.2016
Subjects
Advanced Basic Science
microglia
NADPH oxidase (NOX2)
peripheral benzodiazepine receptor
redox homeostasis
TSPO
TSPO
peripheral benzodiazepine receptor
redox homeostasis
NADPH oxidase (NOX2)
microglia
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Summary:During the past decade, translocator protein 18 kDa (TSPO), previously named peripheral benzodiazepine receptor, has gained a great deal of attention based on its use as a clinical biomarker of neuroinflammation with therapeutic potential. However, there is a paucity of knowledge on the function(s) of TSPO in glial cells. Here, we identify a novel function of TSPO in microglia that is not associated with steroidogenesis. We propose that a TSPO interaction with NADPH oxidase (NOX2) links the generation of reactive oxygen species (ROS) to the induction of an antioxidant response to maintain redox homeostasis. This line of investigation may provide a greater understanding of TSPO glial cell biology, and the knowledge gained may prove beneficial in devising therapeutic strategies.
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ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2016.02.008