Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism

Menadione, vitamin K3, belongs to the class of lipid-soluble vitamins and lipophilic substances as menadione cause disturbances in the bacterial membrane, resulting in damage to the fundamental elements for the integrity of the membrane, thus allowing increased permeability. Accordingly, the aim of...

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Published inSaudi journal of biological sciences Vol. 24; no. 1; pp. 59 - 64
Main Authors Andrade, Jacqueline C., Morais Braga, Maria Flaviana B., Guedes, Gláucia Morgana M., Tintino, Saulo R., Freitas, Maria A., Quintans, Lucindo J., Menezes, Irwin R.A., Coutinho, Henrique D.M.
Format Journal Article
LanguageEnglish
Published Riyadh, Saudi Arabia Elsevier B.V 01.01.2017
Saudi Biological Society
Elsevier
Subjects
Antibiotic-modifying
Lipid solubility
Menadione
Microdilution
Original
Permeabilization
الآثار الفسيولوجية
الأغشية الحيوية
المضادات الحيوية
المكملات الغذائية
المكورات العنقودية
المواد المضادة للبكتيريا
فيتامين ك
Permeabilization
Antibiotic-modifying
Microdilution
Menadione
Lipid solubility
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Summary:Menadione, vitamin K3, belongs to the class of lipid-soluble vitamins and lipophilic substances as menadione cause disturbances in the bacterial membrane, resulting in damage to the fundamental elements for the integrity of the membrane, thus allowing increased permeability. Accordingly, the aim of this study was to evaluate in vitro the antibiotic-modifying activity of menadione in multiresistant strains of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, with a gradual increase in its subinhibitory concentration. In addition, menadione was compared with cholesterol and ergosterol for similarity in mechanism of drug modulatory action. Antibiotic-modifying activity and antibacterial effect were determined by the broth microdilution assay. Menadione, cholesterol and ergosterol showed modulatory activity at clinically relevant concentrations, characterizing them as modifiers of bacterial drug resistance, since they lowered the MIC of the antibiotics tested. This is the first report of the antibacterial activity of menadione and its potentiation of aminoglycosides against multiresistant bacteria.
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ISSN:1319-562X
2213-7106
DOI:10.1016/j.sjbs.2015.09.004