Estrogen receptors alpha and beta in bone

• Published in: Bone (New York, N.Y.) Vol. 87; pp. 130 - 135
• Main Authors: Khalid, Aysha B, Krum, Susan A
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2016
• Subjects: Animals; Bone; Bone and Bones - metabolism; Estrogen; Estrogen receptor alpha (ERα, ESR1); Estrogen Receptor alpha - metabolism; Estrogen receptor beta (ERβ, ESR2); Estrogen Receptor beta - metabolism; Gene Expression Regulation; Humans; Orthopedics; Osteoblasts - metabolism; Osteoclasts - metabolism; Estrogen receptor beta (ERβ, ESR2); Estrogen receptor alpha (ERα, ESR1); Bone; Estrogen
• ISSN: 8756-3282; 1873-2763
• DOI: 10.1016/j.bone.2016.03.016

Abstract Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERβ, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts of the receptors. In vitro and in vivo experiments have shown that ERα and ERβ antagonize each other in bone and in other tissues. This review will highlight the role of these receptors in bone, with particular emphasis on their antagonism.