Phosphatases in SMAD regulation

SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling....

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Bibliographic Details
Published inFEBS letters Vol. 586; no. 14; pp. 1897 - 1905
Main Authors Bruce, David L., Sapkota, Gopal P.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 04.07.2012
Subjects
Animals
BMP
Bone Morphogenetic Proteins - metabolism
Drosophila
Humans
Kinase
Models, Biological
Phosphoprotein Phosphatases - metabolism
Phosphoric Monoester Hydrolases - metabolism
Phosphorylation
Phosphotransferases - metabolism
PPM1A
Protein Phosphatase 2C
Protein Structure, Tertiary
SCP
Signal Transduction
SMAD phosphatase
Smad Proteins - metabolism
TGF beta
Transforming Growth Factor beta - metabolism
SCP
PPM1A
SMAD phosphatase
BMP
TGF beta
Kinase
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Summary:SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2012.02.001