The association of HIV viral load with indirect markers of liver injury

• Published in: Journal of viral hepatitis Vol. 19; no. 2; pp. e202 - e211
• Main Authors: Forrester, J. E., Rhee, M. S., McGovern, B. H., Sterling, R. K., Knox, T. A., Terrin, N.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2012
• Subjects: Adult; antiretroviral therapy; CD4 antigen; Data processing; Enzymes; Enzymes - blood; Female; FIB-4; Hepatitis C; Hepatitis C - complications; Hepatitis C - pathology; Hispanic Americans; HIV; HIV - isolation & purification; HIV Infections - complications; HIV Infections - virology; Human immunodeficiency virus; Humans; Injuries; Liver; Liver - enzymology; Liver - pathology; liver disease; Male; Middle Aged; Platelet Count; Platelets; Prospective Studies; Risk groups; RNA; RNA, Viral - blood; Viral Load
• ISSN: 1352-0504; 1365-2893
• DOI: 10.1111/j.1365-2893.2011.01529.x

This study assessed the association of HIV RNA with indirect markers of liver injury including FIB‐4 index, liver enzymes and platelet counts in a high‐risk Hispanic population. The data were derived from a prospective study that included 138 HIV/hepatitis C (HCV)‐coinfected and 68 HIV‐infected participants without hepatitis C or B co‐infection (mono‐infected). In unadjusted analyses, detectable HIV viral load (vs undetectable, <400 copies/mL) was associated with a 40% greater odds (OR 1.4, 95% CI: 1.1–1.9, P = 0.016) of FIB‐4 > 1.45 in the HIV/HCV‐coinfected group and 70% greater odds of FIB‐4 > 1.45 (OR 1.7, 95% CI: 1.0–2.8; P = 0.046) in the HIV‐mono‐infected group. In multivariable analyses, a 1 log10 increase in HIV RNA was associated with a median increase in FIB‐4 of 12% in the HIV/HCV‐coinfected group and 11% in the HIV‐mono‐infected group (P < 0.0001). Among the HIV/HCV‐coinfected group, the elevating effect of HIV RNA on FIB‐4 was strongest at low CD4 counts (P = 0.0037). Among the HIV‐mono‐infected group, the association between HIV RNA and FIB‐4 was independent of CD4 cell counts. HIV RNA was associated with alterations in both liver enzymes and platelet counts. HIV antiretroviral therapy was not associated with any measure of liver injury examined. This study suggests that HIV may have direct, injurious effects on the liver and that HIV viral load should be considered when these indirect markers are used to assess liver function.