A community standard for immunogenomic data reporting and analysis: proposal for a STrengthening the REporting of Immunogenomic Studies statement

• Published in: Tissue antigens Vol. 78; no. 5; pp. 333 - 344
• Main Authors: Hollenbach, J. A., Mack, S. J., Gourraud, P.-A., Single, R. M., Maiers, M., Middleton, D., Thomson, G., Marsh, S. G. E., Varney, M. D.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2011
• Subjects: Adoption; Computer applications; Conferences; data analysis; data management; Data processing; Genetics, Population - methods; Genome-Wide Association Study; genomics; Genomics - methods; Genomics - statistics & numerical data; Histocompatibility antigen HLA; HLA Antigens - immunology; human leukocyte antigen; Humans; Immune system; Immunogenetics; Killer-cell Immunoglobulin-like Receptor; Nomenclature; Population genetics; reporting guidelines; Research Design - standards; STrengthening the REporting of Genetic Association studies; STrengthening the REporting of Immunogenomic Studies; STrengthening the Reporting of OBservational studies in Epidemiology; Tissue typing
• ISSN: 0001-2815; 1399-0039
• DOI: 10.1111/j.1399-0039.2011.01777.x

Modern high‐throughput HLA and KIR typing technologies are generating a wealth of immunogenomic data with the potential to revolutionize the fields of histocompatibility and immune‐related disease association and population genetic research, much as SNP‐based approaches have revolutionized association research. The STrengthening the REporting of Genetic Association studies (STREGA) statement provides community‐based data reporting and analysis standards for genomic disease‐association studies, identifying specific areas in which adoption of reporting guidelines can improve the consistent interpretation of genetic studies. While aspects of STREGA can be applied to immunogenomic studies, HLA and KIR research requires additional consideration, as the high levels of polymorphism associated with immunogenomic data pose unique methodological and computational challenges to the synthesis of information across datasets. Here, we outline the principle challenges to consistency in immunogenomic studies, and propose that an immunogenomic‐specific analog to the STREGA statement, a STrengthening the REporting of Immunogenomic Studies (STREIS) statement, be developed as part of the 16th International HLA and Immunogenetics Workshop. We propose that STREIS extends at least four of the 22 elements of the STREGA statement to specifically address issues pertinent to immunogenomic data: HLA and KIR nomenclature, data‐validation, ambiguity resolution, and the analysis of highly polymorphic genetic systems. As with the STREGA guidelines, the intent behind STREIS is not to dictate the design of immunogenomic studies, but to ensure consistent and transparent reporting of research, facilitating the synthesis of HLA and KIR data across studies.