Isolation of the Antiulcer Compound in Essential Oil from the Leaves of Cryptomeria japonica

• Published in: Biological & pharmaceutical bulletin Vol. 23; no. 5; pp. 595 - 598
• Main Authors: MATSUNAGA, Takayuki, HASEGAWA, Chika, KAWASUJI, Toru, SUZUKI, Hideyo, SAITO, Haruo, SAGIOKA, Tadashi, TAKAHASHI, Rihei, TSUKAMOTO, Hideko, MORIKAWA, Toshiyuki, AKIYAMA, Takeshi
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01.05.2000; Maruzen; Japan Science and Technology Agency
• Subjects: Acetaldehyde; Animals; Anti-Ulcer Agents - isolation & purification; Anti-Ulcer Agents - therapeutic use; antiulcer activity; Aspirin; Biological and medical sciences; Cryptomeria japonica; Cycadopsida - chemistry; Digestive system; Disease Models, Animal; essential oil; Gastric Juice - metabolism; General pharmacology; Hydrochloric Acid; Male; Medical sciences; Oils, Volatile - chemistry; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Leaves - chemistry; Rats; Rats, Wistar; Stomach Ulcer - chemically induced; Stomach Ulcer - prevention & control; Terpenes - isolation & purification; Terpenes - therapeutic use; terpinen-4-ol; Asia; Japan; Distillation; Rat; Pharmacognosy; Secretion; Rodentia; Oral administration; HPLC chromatography; Antiulcer agent; Biological activity; Medicinal plant; Separation method; Vertebrata; Mammalia; Cryptomeria japonica; Folk medicine; Animal; Sesquiterpenes; Gymnospermae; Monoterpene; Coniferales; Spermatophyta; Essential oil; Gastric juice
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.23.595

Essential oil from the leaves of Tateyamasugi (Cryptomeria japonica) exhibited strong inhibitory activity on ulceration induced by HCl/ethanol, HCl/aspirin, water-immersion stress and pylorus-ligation. We separated the antiulcer compounds from cedar essntial oil by use of distillation and chromatography. As a result, terpinen-4-ol, a monoterpene, and elemol, a sesquiterpene, were isolated as active compounds. The antiulcer activity of the former was more potent than that of the latter. Terpinen-4-ol was a mixture of optical isomers and each possessed potent antiulcer activity. Secretion of gastric juice and output of acid and pepsin activity were lowered by terpinen-4-ol.These results suggest that terpinen-4-ol isolated from cedar essential oil could be a valuable antiulcer agent.