Performance Reassessment of a Real-time Seizure-detection Algorithm on Long ECoG Series

• Published in: Epilepsia (Copenhagen) Vol. 43; no. 12; pp. 1522 - 1535
• Main Authors: Osorio, Ivan, Frei, Mark G., Giftakis, Jon, Peters, Tom, Ingram, Jeff, Turnbull, Mary, Herzog, Michele, Rise, Mark T., Schaffner, Scott, Wennberg, Richard A., Walczak, Thaddeus S., Risinger, Michael W., Ajmone‐Marsan, Cosimo
• Format: Journal Article
• Language: English
• Published: Boston, MA, USA Blackwell Science Inc 01.12.2002; Blackwell
• Subjects: Adolescent; Adult; Algorithm; Algorithms; Biological and medical sciences; Cerebral Cortex - physiopathology; Detection; Diagnosis, Computer-Assisted; Electrodes, Implanted; Electrodiagnosis. Electric activity recording; Electroencephalography; Epilepsies, Partial - diagnosis; Epilepsies, Partial - physiopathology; Epilepsy, Complex Partial - diagnosis; Epilepsy, Complex Partial - physiopathology; Epilepsy, Tonic-Clonic - diagnosis; Epilepsy, Tonic-Clonic - physiopathology; Evoked Potentials - physiology; Female; Fourier Analysis; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Monitoring, Ambulatory; Nervous system; Observer Variation; Reaction Time - physiology; Real-time; Seizure; Sensitivity and Specificity; Signal Processing, Computer-Assisted; Warning; Human; Electrodiagnosis; Convulsion; Real-time-Seizure-Detection- Algorithm-Warning; Neurological disorder; Medical screening; Real time; Algorithm; Electrocorticography
• ISSN: 0013-9580; 1528-1167
• DOI: 10.1046/j.1528-1157.2002.11102.x

Purpose: Automated seizure detection and blockage requires highly sensitive and specific algorithms. This study reassessed the performance of an algorithm by using a more extensive database than that of a previous study and its suitability for safety/efficacy closed‐loop studies to block seizures in humans. Methods: Up to eight electrocorticography (EcoG) channels from 15 subjects were analyzed off‐line. Visual and computerized analyses of the data were performed by different (blinded) investigators. Independent visual analysis also was performed for clinical seizures and for detections identified only by the algorithm. The following were computed: FP rate, number of FNs, latency to automated detection, warning rate for clinical onset and warning times, seizure duration/intensity, and interrater agreement. Adaptations to improve performance were performed when indicated. Results: Fourteen subjects met inclusion criteria. Generic algorithm “relative sensitivity” for clinical seizures was 100%; two undetected subclinical seizures and two unclassified seizures were captured after adaptation. FPs/day were zero in seven and fewer than one in an additional three subjects. Adaptations for four subjects with greater than 1 FP/day (7.7–66.6/day) reduced the rate to 0 in one subject and to fewer than five FP/day (1.7–4.2/day) in the remainder. Generic latency to automated detection was <5 s in eight of 13 subjects, and in 12 of 13 after adaptation. Detections provided warning of clinical onset in three of four subjects in whom it always followed electrographic onset, and in four of four after adaptation. Interrater agreement was low for FPs and EDs. Conclusions: The generic algorithm demonstrated high sensitivity, specificity, and speed, characteristics further enhanced by adaptation. This algorithm is well suited for seizure detection/warning and use in safety/efficacy closed‐loop therapy studies.