Association of a CD24 gene polymorphism with susceptibility to systemic lupus erythematosus

• Published in: Arthritis and rheumatism Vol. 56; no. 9; pp. 3080 - 3086
• Main Authors: Sánchez, Elena, Abelson, Anna‐Karin, Sabio, Jose M., González‐Gay, Miguel A., Ortego‐Centeno, Norberto, Jiménez‐Alonso, Juan, de Ramón, Enrique, Sánchez‐Román, Julio, López‐Nevot, Miguel A., Gunnarsson, Iva, Svenungsson, Elisabet, Sturfelt, Gunnar, Truedsson, Lennart, Jönsen, Andreas, González‐Escribano, Maria Francisca, Witte, Torsten, Alarcón‐Riquelme, Marta E., Martín, Javier
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2007; Wiley
• Subjects: Biological and medical sciences; CD24 Antigen - genetics; Clinical Medicine; Cohort Studies; Female; Genetic Predisposition to Disease; Humans; Klinisk medicin; Lupus Erythematosus, Systemic - genetics; Male; Medical and Health Sciences; Medical sciences; MEDICIN; Medicin och hälsovetenskap; MEDICINE; Polymorphism, Genetic; Reumatologi och inflammation; Rheumatology and Autoimmunity; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Human; Polymerase chain reaction; Immunopathology; Connective tissue disease; Skin disease; Systemic lupus erythematosus; Systemic disease; Autoimmune disease; Molecular biology; Polymorphism; Lupus Erythematosus; Genetic; Antigens; CD24/genetics; Systemic/genetics
• ISSN: 0004-3591; 1529-0131; 1529-0131
• DOI: 10.1002/art.22871

Objective To determine the potential role of the CD24 A57V gene polymorphism in systemic lupus erythematosus (SLE). Methods We studied 3 cohorts of Caucasian patients and controls. The Spanish cohort included 696 SLE patients and 539 controls, the German cohort included 257 SLE patients and 317 controls, and the Swedish cohort included 310 SLE patients and 247 controls. The CD24 A57V polymorphism was genotyped by polymerase chain reaction, using a predeveloped TaqMan allele discrimination assay. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results In the Spanish cohort there was a statistically significant difference in the distribution of the CD24 V allele between SLE patients and controls (OR 3.6 [95% CI 2.13–6.16], P < 0.0001). In addition, frequency of the CD24 V/V genotype was increased in SLE patients compared with controls (OR 3.7 [95% CI 2.16–6.34], P < 0.00001). We sought to replicate this association with SLE in a German population and a Swedish population. A similar trend was found in the German group. The CD24 V/V genotype and the CD24 V allele were more frequent in SLE patients than in controls, although this difference was not statistically significant. No differences were observed in the Swedish group. A meta‐analysis of the Spanish and German cohorts demonstrated that the CD24 V allele has a risk effect in SLE patients (pooled OR 1.25 [95% CI 1.08–1.46], P = 0.003). In addition, homozygosity for the CD24 V risk allele significantly increased the effect (pooled OR 2.19 [95% CI 1.50–3.22], P = 0.00007). Conclusion These findings suggest that the CD24 A57V polymorphism plays a role in susceptibility to SLE in a Spanish population.