Diacetyl odor shortens longevity conferred by food deprivation in C. elegans via downregulation of DAF‐16/FOXO

• Published in: Aging cell Vol. 20; no. 1; pp. e13300 - n/a
• Main Authors: Park, Sangsoon, Artan, Murat, Jeong, Dae‐Eun, Park, Hae‐Eun H., Son, Heehwa G., Kim, Sieun S., Jung, Yoonji, Choi, Yunji, Lee, Jin I., Kim, Kyuhyung, Lee, Seung‐Jae V.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.01.2021; John Wiley and Sons Inc
• Subjects: aging; Alcohol; Attractants; Bacteria; C. elegans; Chemical stimuli; Chemicals; Diacetyl; dietary restriction; Dietary restrictions; E coli; Experiments; Food; Forkhead protein; Functional foods; Insects; Insulin; Insulin-like growth factors; Lactic acid; Lactic acid bacteria; Life span; Longevity; Nutrients; Odor; Odors; Physiology; Sensory evaluation; Sensory neurons; Short Take; Statistical analysis; longevity; C. elegans; aging; diacetyl; dietary restriction
• ISSN: 1474-9718; 1474-9726
• DOI: 10.1111/acel.13300

Dietary restriction extends lifespan in various organisms by reducing the levels of both nutrients and non‐nutritional food‐derived cues. However, the identity of specific food‐derived chemical cues that alter lifespan remains unclear. Here, we identified several volatile attractants that decreased the longevity on food deprivation, a dietary restriction regimen in Caenorhabditis elegans. In particular, we found that the odor of diacetyl decreased the activity of DAF‐16/FOXO, a life‐extending transcription factor acting downstream of insulin/IGF‐1 signaling. We then demonstrated that the odor of lactic acid bacteria, which produce diacetyl, reduced the nuclear accumulation of DAF‐16/FOXO. Unexpectedly, we showed that the odor of diacetyl decreased longevity independently of two established diacetyl receptors, ODR‐10 and SRI‐14, in sensory neurons. Thus, diacetyl, a food‐derived odorant, may shorten food deprivation‐induced longevity via decreasing the activity of DAF‐16/FOXO through binding to unidentified receptors. Food deprivation, a dietary restriction regimen in C. elegans, promotes longevity by increasing nuclear localization and transcriptional activity of DAF‐16/FOXO. The odor of diacetyl, a volatile organic compound that is produced by lactic acid bacteria, decreases food deprivation‐mediated longevity by downregulating DAF‐16/FOXO via an unidentified receptor. Our data indicate that specific food odors can reduce longevity in animals.