Cryptosporidium parvum IId family: clonal population and dispersal from Western Asia to other geographical regions

In this study, 111 Cryptosporidium parvum IId isolates from several species of animals in China, Sweden and Egypt were subtyped by multilocus sequence typing (MLST). One to eleven subtypes were detected at each of the 12 microsatellite, minisatellite and single nucleotide polymorphism (SNP) loci, fo...

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Published inScientific reports Vol. 4; no. 1; p. 4208
Main Authors Wang, Rongjun, Zhang, Longxian, Axén, Charlotte, Bjorkman, Camilla, Jian, Fuchun, Amer, Said, Liu, Aiqin, Feng, Yaoyu, Li, Guoquan, Lv, Chaochao, Zhao, Zifang, Qi, Meng, Dong, Haiju, Wang, Helei, Sun, Yanru, Ning, Changshen, Xiao, Lihua
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 27.02.2014
Nature Publishing Group
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Summary:In this study, 111 Cryptosporidium parvum IId isolates from several species of animals in China, Sweden and Egypt were subtyped by multilocus sequence typing (MLST). One to eleven subtypes were detected at each of the 12 microsatellite, minisatellite and single nucleotide polymorphism (SNP) loci, forming 25 MLST subtypes. Host-adaptation and significant geographical segregation were both observed in the MLST subtypes. A clonal population structure was seen in C. parvum IId isolates from China and Sweden. Three ancestral lineages and the same RPGR sequence were shared by these isolates examined. Therefore, the present genetic observations including the higher nucleotide diversity of C. parvum IId GP60 sequences in Western Asia, as well as the unique distribution of IId subtypes (almost exclusively found in Asia, Europe and Egypt) and in combination with the domestication history of cattle, sheep and goats, indicated that C. parvum IId subtypes were probably dispersed from Western Asia to other geographical regions. More population genetic structure studies involving various C. parvum subtype families using high-resolution tools are needed to better elucidate the origin and dissemination of C. parvum in the world.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep04208