DGIdb: mining the druggable genome
A database of known drug-gene interactions, with information derived from many public sources, allows the identification of genes that are currently targeted by a drug and the membership of genes in a category, such as kinase genes, that have a high potential for drug development. The Drug-Gene Inte...
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Published in | Nature methods Vol. 10; no. 12; pp. 1209 - 1210 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Nature Publishing Group US
01.12.2013
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Abstract | A database of known drug-gene interactions, with information derived from many public sources, allows the identification of genes that are currently targeted by a drug and the membership of genes in a category, such as kinase genes, that have a high potential for drug development.
The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at
http://dgidb.org/
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AbstractList | The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at http://dgidb.org/. A database of known drug-gene interactions, with information derived from many public sources, allows the identification of genes that are currently targeted by a drug and the membership of genes in a category, such as kinase genes, that have a high potential for drug development. The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at http://dgidb.org/ . The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially druggable genes. DGIdb can be accessed at dgidb.org. |
Audience | Academic |
Author | Wilson, Richard K Larson, David E Smith, Scott M McMichael, Josh F Das, Indraniel Griffith, Malachi Govindan, Ramaswamy Coffman, Adam C Mardis, Elaine R Callaway, Matthew B Spies, Nicholas C Bose, Ron Ley, Timothy J Weible, James V Walker, Jason R Dooling, David J Koval, James Kumar, Runjun D Subramanian, Janakiraman Griffith, Obi L Eldred, James M Ding, Li Miller, Christopher A |
AuthorAffiliation | 1 The Genome Institute, Washington University School of Medicine, St. Louis, MO 2 Department of Genetics, Washington University School of Medicine, St. Louis, MO 4 Siteman Cancer Center, Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, MO 3 Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO |
AuthorAffiliation_xml | – name: 2 Department of Genetics, Washington University School of Medicine, St. Louis, MO – name: 1 The Genome Institute, Washington University School of Medicine, St. Louis, MO – name: 4 Siteman Cancer Center, Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, MO – name: 3 Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO |
Author_xml | – sequence: 1 givenname: Malachi orcidid: 0000-0002-6388-446X surname: Griffith fullname: Griffith, Malachi email: mgriffit@genome.wustl.edu organization: The Genome Institute, Washington University School of Medicine, Department of Genetics, Washington University School of Medicine – sequence: 2 givenname: Obi L surname: Griffith fullname: Griffith, Obi L email: ogriffit@genome.wustl.edu organization: The Genome Institute, Washington University School of Medicine, Department of Medicine, Division of Oncology, Washington University School of Medicine – sequence: 3 givenname: Adam C surname: Coffman fullname: Coffman, Adam C organization: The Genome Institute, Washington University School of Medicine – sequence: 4 givenname: James V surname: Weible fullname: Weible, James V organization: The Genome Institute, Washington University School of Medicine – sequence: 5 givenname: Josh F surname: McMichael fullname: McMichael, Josh F organization: The Genome Institute, Washington University School of Medicine – sequence: 6 givenname: Nicholas C surname: Spies fullname: Spies, Nicholas C organization: The Genome Institute, Washington University School of Medicine – sequence: 7 givenname: James surname: Koval fullname: Koval, James organization: The Genome Institute, Washington University School of Medicine – sequence: 8 givenname: Indraniel surname: Das fullname: Das, Indraniel organization: The Genome Institute, Washington University School of Medicine – sequence: 9 givenname: Matthew B surname: Callaway fullname: Callaway, Matthew B organization: The Genome Institute, Washington University School of Medicine – sequence: 10 givenname: James M surname: Eldred fullname: Eldred, James M organization: The Genome Institute, Washington University School of Medicine – sequence: 11 givenname: Christopher A surname: Miller fullname: Miller, Christopher A organization: The Genome Institute, Washington University School of Medicine – sequence: 12 givenname: Janakiraman surname: Subramanian fullname: Subramanian, Janakiraman organization: Department of Medicine, Division of Oncology, Washington University School of Medicine – sequence: 13 givenname: Ramaswamy surname: Govindan fullname: Govindan, Ramaswamy organization: Department of Medicine, Division of Oncology, Washington University School of Medicine – sequence: 14 givenname: Runjun D surname: Kumar fullname: Kumar, Runjun D organization: Department of Medicine, Division of Oncology, Washington University School of Medicine – sequence: 15 givenname: Ron surname: Bose fullname: Bose, Ron organization: Department of Medicine, Division of Oncology, Washington University School of Medicine, Siteman Cancer Center, Barnes-Jewish Hospital, Washington University School of Medicine – sequence: 16 givenname: Li surname: Ding fullname: Ding, Li organization: The Genome Institute, Washington University School of Medicine, Department of Genetics, Washington University School of Medicine, Department of Medicine, Division of Oncology, Washington University School of Medicine – sequence: 17 givenname: Jason R surname: Walker fullname: Walker, Jason R organization: The Genome Institute, Washington University School of Medicine – sequence: 18 givenname: David E surname: Larson fullname: Larson, David E organization: The Genome Institute, Washington University School of Medicine, Department of Genetics, Washington University School of Medicine – sequence: 19 givenname: David J surname: Dooling fullname: Dooling, David J organization: The Genome Institute, Washington University School of Medicine – sequence: 20 givenname: Scott M surname: Smith fullname: Smith, Scott M organization: The Genome Institute, Washington University School of Medicine – sequence: 21 givenname: Timothy J surname: Ley fullname: Ley, Timothy J organization: The Genome Institute, Washington University School of Medicine, Department of Medicine, Division of Oncology, Washington University School of Medicine, Siteman Cancer Center, Barnes-Jewish Hospital, Washington University School of Medicine – sequence: 22 givenname: Elaine R surname: Mardis fullname: Mardis, Elaine R organization: The Genome Institute, Washington University School of Medicine, Department of Genetics, Washington University School of Medicine, Siteman Cancer Center, Barnes-Jewish Hospital, Washington University School of Medicine – sequence: 23 givenname: Richard K surname: Wilson fullname: Wilson, Richard K organization: The Genome Institute, Washington University School of Medicine, Department of Genetics, Washington University School of Medicine, Siteman Cancer Center, Barnes-Jewish Hospital, Washington University School of Medicine |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24122041$$D View this record in MEDLINE/PubMed |
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Snippet | A database of known drug-gene interactions, with information derived from many public sources, allows the identification of genes that are currently targeted... The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or... |
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SubjectTerms | 631/114/129 631/114/2164 631/114/2401 631/154 Antineoplastic Agents - chemistry Bioinformatics Biological Microscopy Biological Techniques Biomedical Engineering/Biotechnology Breast Neoplasms - drug therapy Breast Neoplasms - genetics brief-communication Computational Biology - methods Data Mining - methods Databases, Genetic Drug Discovery - methods Drug Interactions Drug therapy Gene Expression Regulation - drug effects Gene mutations Genes Genetic Variation Genome Genomes Genomics Genomics - methods Humans Information services Life Sciences Lung Neoplasms - drug therapy Lung Neoplasms - genetics Mines Mutation Online information services Online services Pharmaceutical research Proteomics Services Software Technology, Pharmaceutical - methods |
Title | DGIdb: mining the druggable genome |
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