DGIdb: mining the druggable genome

A database of known drug-gene interactions, with information derived from many public sources, allows the identification of genes that are currently targeted by a drug and the membership of genes in a category, such as kinase genes, that have a high potential for drug development. The Drug-Gene Inte...

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Bibliographic Details
Published inNature methods Vol. 10; no. 12; pp. 1209 - 1210
Main Authors Griffith, Malachi, Griffith, Obi L, Coffman, Adam C, Weible, James V, McMichael, Josh F, Spies, Nicholas C, Koval, James, Das, Indraniel, Callaway, Matthew B, Eldred, James M, Miller, Christopher A, Subramanian, Janakiraman, Govindan, Ramaswamy, Kumar, Runjun D, Bose, Ron, Ding, Li, Walker, Jason R, Larson, David E, Dooling, David J, Smith, Scott M, Ley, Timothy J, Mardis, Elaine R, Wilson, Richard K
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.12.2013
Nature Publishing Group
Subjects
631/114/129
631/114/2164
631/114/2401
631/154
Antineoplastic Agents - chemistry
Bioinformatics
Biological Microscopy
Biological Techniques
Biomedical Engineering/Biotechnology
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
brief-communication
Computational Biology - methods
Data Mining - methods
Databases, Genetic
Drug Discovery - methods
Drug Interactions
Drug therapy
Gene Expression Regulation - drug effects
Gene mutations
Genes
Genetic Variation
Genome
Genomes
Genomics
Genomics - methods
Humans
Information services
Life Sciences
Lung Neoplasms - drug therapy
Lung Neoplasms - genetics
Mines
Mutation
Online information services
Online services
Pharmaceutical research
Proteomics
Services
Software
Technology, Pharmaceutical - methods
United States
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Summary:A database of known drug-gene interactions, with information derived from many public sources, allows the identification of genes that are currently targeted by a drug and the membership of genes in a category, such as kinase genes, that have a high potential for drug development. The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at http://dgidb.org/ .
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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These authors contributed equally to this work.
ISSN:1548-7091
1548-7105
DOI:10.1038/nmeth.2689