Sensitization to cashew nut 2S albumin, Ana o 3, is highly predictive of cashew and pistachio allergy in Greek children
A very high correlation between cashew- and pistachio-specific IgE levels (Spearman correlation coefficient rs = 0.95) has been previously reported, suggesting significant serologic cross-reactivity.5 Conventional IgE assays have been shown to be suboptimally specific for either cashew nut or pistac...
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Published in | Journal of allergy and clinical immunology Vol. 136; no. 1; pp. 192 - 194 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.07.2015
Elsevier Limited |
Subjects | |
Online Access | Get full text |
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Summary: | A very high correlation between cashew- and pistachio-specific IgE levels (Spearman correlation coefficient rs = 0.95) has been previously reported, suggesting significant serologic cross-reactivity.5 Conventional IgE assays have been shown to be suboptimally specific for either cashew nut or pistachio allergy, thus leaving a "gray area" with positive results of uncertain clinical significance.5,6 The aim of the present study was to investigate the utility of recombinant cashew 2S albumin Ana o 3 in the diagnosis of cashew nut allergy and to explore its relevance in the diagnosis of associated pistachio allergy. [...]in our population, 13 of 15 patients falsely labeled as allergic to cashew by detection of cashew-specific IgE would have been correctly classified by subsequent measurement of IgE levels to rAna o 3. |
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Bibliography: | SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 |
ISSN: | 0091-6749 1097-6825 1097-6825 |
DOI: | 10.1016/j.jaci.2015.03.037 |