Biofunctional Sr- and Si-loaded titania nanotube coating of Ti surfaces by anodization-hydrothermal process

• Published in: International journal of nanomedicine Vol. 13; pp. 633 - 640
• Main Authors: Huang, Yong, Shen, Xue, Qiao, Haixia, Yang, Hao, Zhang, Xuejiao, Liu, Yiyao, Yang, Hejie
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2018; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Animals; Cell adhesion & migration; Cell Adhesion - drug effects; Cell Differentiation - drug effects; Cell Proliferation - drug effects; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - pharmacology; Coatings; Contact angle; Corrosion; Corrosion (Chemistry); Corrosion resistance; Cytocompatibility; Electrolytes; Fluorides; Hydroxyapatite; Laboratories; Materials Testing; Mice; Morphology; Nanotechnology - methods; Nanotubes; Nanotubes - chemistry; Original Research; Osteoblasts - cytology; Osteoblasts - drug effects; Silicon; Silicon - chemistry; Strontium; Strontium - chemistry; Surface Properties; TiO2 nanotube; Titanium; Titanium - chemistry; Titanium alloys; Topography; Transplants & implants; United States > US; China; cytocompatibility; TiO2 nanotube; silicon; corrosion resistance; strontium
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/IJN.S147969

Two frequent problems associated with titanium (Ti) surfaces of bone/dental implants are their corrosion and lack of native tissue integration. Here, we present an anodization-hydrothermal method for coating Ti surfaces with a layer of silicon (Si)- and strontium (Sr)-loaded titania nanotubes (TNs). The Ti surfaces coated with such a layer (Si-Sr-TNs) were characterized with different techniques. The results indicate that the Si and Sr ions were evenly incorporated into the TNs and that the Si-Sr-TN layer provides good protection against corrosive media like simulated body fluid. The excellent cytocompatibility of the coating was confirmed in vitro by the significant growth and differentiation of MC3T3-E1 osteoblastic cells. Being easily and economically fabricated, the Si-Sr-TN surfaces may find their niche in clinical applications, thanks to their excellent biological activity and corrosion resistance.