Liquid Embolization of Peripheral Arteriovenous Malformations with Ethylene-Vinyl Alcohol Copolymer in Neonates and Infants

In the postnatal period, extensive peripheral arteriovenous malformations (AVM) are associated with high morbidity, especially when localized in the liver. Their urgent treatment is always a challenging problem in neonates and infants. We analyzed four consecutive children aged three days to three y...

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Published inCardiovascular therapeutics Vol. 2022; pp. 1022729 - 8
Main Authors Pfeifer, Jochen, Wohlgemuth, Walter A., Abdul-Khaliq, Hashim
Format Journal Article
LanguageEnglish
Published England Hindawi 18.07.2022
Hindawi Limited
Wiley
Subjects
Alcohol
Arteriovenous malformations
Arteriovenous Malformations - drug therapy
Arteriovenous Malformations - therapy
Catheters
Child
Child, Preschool
Circulatory system
Embolization
Embolization, Therapeutic - adverse effects
Embolization, Therapeutic - methods
Ethylene
Heart failure
Humans
Infant, Newborn
Infants (Newborn)
Intubation
Liver
Localization
Medical imaging
Newborn babies
Patients
Polymerization
Polyvinyls - adverse effects
Pulmonary hypertension
Skin
Treatment Outcome
Veins & arteries
United States > US
California
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Summary:In the postnatal period, extensive peripheral arteriovenous malformations (AVM) are associated with high morbidity, especially when localized in the liver. Their urgent treatment is always a challenging problem in neonates and infants. We analyzed four consecutive children aged three days to three years who underwent eight liquid embolization procedures with ethylene-vinyl alcohol copolymer. The AVM were situated on the thoracic wall, in the liver, and on the lower leg. In three cases, the malformations showed total regression. The tibial AVM degenerated widely. If impaired beforehand, cardiac or hepatic function normalized after the interventions. There were no embolization-associated complications such as nontarget embolization or tissue ischemia. We conclude that application of ethylene-vinyl alcohol copolymer seems to be a safe therapeutic option and can be used in neonates and infants with peripheral AVM in consideration of the agent’s characteristics. Nevertheless, there are still hardly any data concerning young children.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Academic Editor: Abhishesh Mehata
ISSN:1755-5914
1755-5922
1755-5922
DOI:10.1155/2022/1022729