Clinical Significance of Trace Element Zinc in Patients with Chronic Kidney Disease

The trace element zinc is essential for diverse physiological processes in humans. Zinc deficiency can impair growth, skin reproduction, immune function, maintenance of taste, glucose metabolism, and neurological function. Patients with chronic kidney disease (CKD) are susceptible to zinc deficiency...

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Published inJournal of clinical medicine Vol. 12; no. 4; p. 1667
Main Authors Fukasawa, Hirotaka, Furuya, Ryuichi, Kaneko, Mai, Nakagami, Daisuke, Ishino, Yuri, Kitamoto, Shuhei, Omata, Kyosuke, Yasuda, Hideo
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.02.2023
MDPI
Subjects
Adipocytes
Analysis
Anemia
Bioavailability
Body mass index
cardiovascular disease
Chronic illnesses
chronic kidney disease
Chronic kidney failure
Clinical medicine
Clinical significance
Communication
Complications and side effects
copper
Dehydrogenases
Diabetes
Disease susceptibility
Enzymes
Glucose metabolism
Health aspects
Hemodialysis
Hemoglobin
Iron
Kidney diseases
Metabolism
Mortality
nutrition
Peritoneal dialysis
Plasma
Prevention
Proteins
Renal anemia
Risk factors
Transcription factors
Tumor necrosis factor-TNF
Vegetarianism
zinc
Zinc in the body
Japan
cardiovascular disease
copper
chronic kidney disease
nutrition
zinc
anemia
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Summary:The trace element zinc is essential for diverse physiological processes in humans. Zinc deficiency can impair growth, skin reproduction, immune function, maintenance of taste, glucose metabolism, and neurological function. Patients with chronic kidney disease (CKD) are susceptible to zinc deficiency, which is associated with erythropoiesis-stimulating agent (ESA) hypo-responsive anemia, nutritional problems, and cardiovascular diseases as well as non-specific symptoms such as dermatitis, prolonged wound healing, taste disturbance, appetite loss, or cognitive decline. Thus, zinc supplementation may be useful for the treatment of its deficiency, although it often causes copper deficiency, which is characterized by several severe disorders including cytopenia and myelopathy. In this review article, we mainly discuss the significant roles of zinc and the association between zinc deficiency and the pathogenesis of complications in patients with CKD.
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12041667