Screening of Crude Drugs for Influence on Amylase Activity and Postprandial Blood Glucose in Mouse Plasma

• Published in: Biological & pharmaceutical bulletin Vol. 23; no. 10; pp. 1250 - 1253
• Main Authors: KOBAYASHI, Kyoko, SAITO, Yuka, NAKAZAWA, Ikuko, YOSHIZAKI, Fumihiko
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01.10.2000; Maruzen; Japan Science and Technology Agency
• Subjects: alpha-Amylases - metabolism; Animals; Biological and medical sciences; Blood Glucose - metabolism; blood plasma; crude drug; Drugs, Chinese Herbal - pharmacology; General pharmacology; Glycogen - metabolism; Male; Medical sciences; Mice; mouse; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - pharmacology; postprandial blood glucose; Postprandial Period - physiology; α-amylase; Monocotyledones; Intraperitoneal administration; Glucose; Blood; Medicinal plant; Blood plasma; Dose activity relation; Chinese medicine; Enzymatic activity; Dicotyledones; Angiospermae; Clematis; α-Amylase; Zingiber officinale; Enzyme; Pharmacognosy; Ranunculaceae; Rodentia; Oral administration; Enzyme inhibitor; In vitro; Biological activity; In vivo; Vertebrata; Mammalia; Mouse; Glycosidases; Animal; Plant origin; Hydrolases; Spermatophyta; Aconitum; O-Glycosidases; Phytolaccaceae; Zingiberaceae
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.23.1250

Screening of crude drugs for inhibitory activity on α-amylase in mouse plasma was performed. Hot water extracts and ethanolic extracts of Arecae Semen, Ephedrae Herba, Malloti Cortex, Rhei Rhizoma and ethanolic extract of Moutan Cortex inhibited enzyme activity in isolated mouse plasma strongly and dose-dependently. However, the effects of these 9 extracts were not observed in the plasma when they were administered intraperitoneally or orally. Ethanolic extract of Arecae Semen also showed a depressive effect on elevation of postprandial blood glucose.