Two diagnoses become one? Rare case report of anorexia nervosa and Cushing's syndrome

Hypothalamic-pituitary-adrenal axis impairment in anorexia nervosa is marked by hypercortisolemia, and psychiatric disorders occur in the majority of patients with Cushing's syndrome. Here we report a patient diagnosed with anorexia nervosa who also developed Cushing's syndrome. A 26-year-...

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Published inNeuropsychiatric disease and treatment Vol. 9; no. default; pp. 431 - 435
Main Authors Sawicka, Nadia, Gryczyńska, Maria, Sowiński, Jerzy, Tamborska-Zedlewska, Monika, Ruchała, Marek
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2013
Taylor & Francis Ltd
Dove Press
Dove Medical Press
Subjects
Adrenal glands
Adrenalectomy
Adrenocorticotropic hormone
Amenorrhea
Analysis
Anorexia
Anorexia nervosa
Care and treatment
Case Report
Case reports
Computed tomography
CT imaging
Cushing syndrome
Cushing's syndrome
Diagnosis
Eating disorders
Hypokalemia
Hypothalamic-pituitary-adrenal axis
Hypothalamus
Laparoscopy
Medical diagnosis
Mental depression
Mental disorders
Nervous system diseases
Osteoporosis
Patients
Pituitary
Schizophrenia
Symptomatology
adrenalectomy
Cushing’s syndrome
anorexia nervosa
osteoporosis
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Summary:Hypothalamic-pituitary-adrenal axis impairment in anorexia nervosa is marked by hypercortisolemia, and psychiatric disorders occur in the majority of patients with Cushing's syndrome. Here we report a patient diagnosed with anorexia nervosa who also developed Cushing's syndrome. A 26-year-old female had been treated for anorexia nervosa since she was 17 years old, and also developed depression and paranoid schizophrenia. She was admitted to the Department of Endocrinology, Metabolism, and Internal Medicine with a preliminary diagnosis of Cushing's syndrome. Computed tomography revealed a 27 mm left adrenal tumor, and she underwent laparoscopic adrenalectomy. She was admitted to hospital 6 months after this procedure, at which time she did not report any eating or mood disorder. This is a rare case report of a patient with anorexia nervosa in whom Cushing's syndrome was subsequently diagnosed. Diagnostic difficulties were caused by the signs and symptoms presenting in the course of both disorders, ie, hypercortisolemia, osteoporosis, secondary amenorrhea, striae, hypokalemia, muscle weakness, and depression.
Bibliography:These authors contributed equally to this work
ISSN:1176-6328
1176-6328
1178-2021
DOI:10.2147/NDT.S40398