Oleocanthal Ameliorates Amyloid-β Oligomers Toxicity on Astrocytes and Neuronal Cells: In-vitro Studies
Highlights • Oleocanthal rectified Aβo-induced pathological changes in astrocytes and neurons in-vitro. • Oleocanthal reduced astrocytes activation and inflammation associated with Aβ oligomers exposure. • The neuroprotective effect of oleocanthal could be direct and not mediated by astrocytes....
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| Published in | Neuroscience Vol. 352; pp. 204 - 215 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Ltd
03.06.2017
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| Abstract | Highlights • Oleocanthal rectified Aβo-induced pathological changes in astrocytes and neurons in-vitro. • Oleocanthal reduced astrocytes activation and inflammation associated with Aβ oligomers exposure. • The neuroprotective effect of oleocanthal could be direct and not mediated by astrocytes. |
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| AbstractList | Extra-virgin olive oil (EVOO) has several health promoting effects. Evidence have shown that EVOO attenuates the pathology of amyloid-β (Aβ) and improves cognitive function in experimental animal models, suggesting it's potential to protect and reduce the risk of developing Alzheimer's disease (AD). Available studies have linked this beneficial effect to oleocanthal, one of the active components in EVOO. The effect of oleocanthal against AD pathology has been linked to its ability to attenuate Aβ and tau aggregation in vitro, and enhance Aβ clearance from the brains of wild-type and AD transgenic mice in vivo. However, the ability of oleocanthal to alter the toxic effect of Aβ on brain parenchymal cells is unknown. In the current study, we investigated oleocanthal effect on modulating Aβ oligomers (Aβo) pathological events in neurons and astrocytes. Our findings demonstrated oleocanthal prevented Aβo-induced synaptic proteins, SNAP-25 and PSD-95, down-regulation in neurons, and attenuated Aβo-induced inflammation, glutamine transporter (GLT1) and glucose transporter (GLUT1) down-regulation in astrocytes. Aβo-induced inflammation was characterized by interleukin-6 (IL-6) increase and glial fibrillary acidic protein (GFAP) upregulation that were reduced by oleocanthal. In conclusion, this study provides further evidence to support the protective effect of EVOO-derived phenolic secoiridoid oleocanthal against AD pathology. Highlights • Oleocanthal rectified Aβo-induced pathological changes in astrocytes and neurons in-vitro. • Oleocanthal reduced astrocytes activation and inflammation associated with Aβ oligomers exposure. • The neuroprotective effect of oleocanthal could be direct and not mediated by astrocytes. •Oleocanthal rectified Aβo-induced pathological changes in astrocytes and neurons in vitro.•Oleocanthal reduced astrocyte activation and inflammation associated with Aβ oligomer exposure.•The neuroprotective effect of oleocanthal could be direct and not mediated by astrocytes. Extra-virgin olive oil (EVOO) has several health promoting effects. Evidence have shown that EVOO attenuates the pathology of amyloid-β (Aβ) and improves cognitive function in experimental animal models, suggesting it’s potential to protect and reduce the risk of developing Alzheimer’s disease (AD). Available studies have linked this beneficial effect to oleocanthal, one of the active components in EVOO. The effect of oleocanthal against AD pathology has been linked to its ability to attenuate Aβ and tau aggregation in vitro, and enhance Aβ clearance from the brains of wild-type and AD transgenic mice in vivo. However, the ability of oleocanthal to alter the toxic effect of Aβ on brain parenchymal cells is unknown. In the current study, we investigated oleocanthal effect on modulating Aβ oligomers (Aβo) pathological events in neurons and astrocytes. Our findings demonstrated oleocanthal prevented Aβo-induced synaptic proteins, SNAP-25 and PSD-95, down-regulation in neurons, and attenuated Aβo-induced inflammation, glutamine transporter (GLT1) and glucose transporter (GLUT1) down-regulation in astrocytes. Aβo-induced inflammation was characterized by interleukin-6 (IL-6) increase and glial fibrillary acidic protein (GFAP) upregulation that were reduced by oleocanthal. In conclusion, this study provides further evidence to support the protective effect of EVOO-derived phenolic secoiridoid oleocanthal against AD pathology. |
| Author | Batarseh, Yazan S Siddique, Abu Bakar Mohamed, Loqman A Mousa, Youssef M El Sayed, Khalid A Kaddoumi, Amal Al Rihani, Sweilem B |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28392295$$D View this record in MEDLINE/PubMed |
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| Keywords | APP BBB DMSO Extra-virgin olive oil Radioimmunoprecipitation assay IDE Blood brain barrier Insulin-degrading enzyme RIPA Aβ oligomers Interleukin-6 Aβ BSA soluble APPβ Apolipoprotein E Phosphate buffer saline ApoE Amyloid-β ABCA1 Glucose transporter PBS Bovine serum albumin GLUT1 AD GLT1 Alzheimer’s disease Astrocytes Neurons Astrocytes conditioned media Glial fibrillary acidic protein Aβ monomer Soluble APPα Neuroinflammation ACM Oleocanthal Amyloid precursor protein IL-6 GFAP sAPPα EVOO ATP-binding cassette transporter-A1 Glutamate transporter Dimethyl sulfoxide sAPPβ Aβm Aβo neurons oleocanthal neuroinflammation amyloid-β astrocytes |
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| Snippet | Highlights • Oleocanthal rectified Aβo-induced pathological changes in astrocytes and neurons in-vitro. • Oleocanthal reduced astrocytes activation and... •Oleocanthal rectified Aβo-induced pathological changes in astrocytes and neurons in vitro.•Oleocanthal reduced astrocyte activation and inflammation... Extra-virgin olive oil (EVOO) has several health promoting effects. Evidence have shown that EVOO attenuates the pathology of amyloid-β (Aβ) and improves... |
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| SubjectTerms | Aldehydes - pharmacology Amyloid beta-Peptides - toxicity Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism amyloid-β Anti-Inflammatory Agents - pharmacology astrocytes Astrocytes - drug effects Cell Line, Tumor Disks Large Homolog 4 Protein - metabolism Dose-Response Relationship, Drug Glutamate Plasma Membrane Transport Proteins - metabolism Humans Interleukin-6 - metabolism Nerve Tissue Proteins - metabolism neuroinflammation Neurology neurons Neurons - drug effects oleocanthal Phenols - pharmacology Synaptosomal-Associated Protein 25 - metabolism Time Factors Transfection |
| Title | Oleocanthal Ameliorates Amyloid-β Oligomers Toxicity on Astrocytes and Neuronal Cells: In-vitro Studies |
| URI | https://www.clinicalkey.es/playcontent/1-s2.0-S0306452217302348 https://dx.doi.org/10.1016/j.neuroscience.2017.03.059 https://www.ncbi.nlm.nih.gov/pubmed/28392295 https://pubmed.ncbi.nlm.nih.gov/PMC5504696 |
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