Inter-hemispheric functional connectivity changes with corpus callosum morphology in multiple sclerosis

• Published in: Neuroscience Vol. 266; pp. 47 - 55
• Main Authors: Zito, G, Luders, E, Tomasevic, L, Lupoi, D, Toga, A.W, Thompson, P.M, Rossini, P.M, Filippi, M.M, Tecchio, F
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 25.04.2014
• Subjects: Adult; corpus callosum; Corpus Callosum - pathology; Corpus Callosum - physiopathology; Electroencephalography; electroencephalography/event-related potentials (EEG/ERPs); Female; Functional Laterality - physiology; Hand Strength; Humans; Image Interpretation, Computer-Assisted; inter-hemispheric coherence; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting - pathology; Multiple Sclerosis, Relapsing-Remitting - physiopathology; Neurology; relapsing-remitting multiple sclerosis (RRMS); sensorimotor control; structural magnetic resonance imaging; RR; magnetic resonance imaging; MRI; relapsing-remitting multiple sclerosis (RRMS); electroencephalography/event-related potentials (EEG/ERPs); Expanded Disability Status Scale; relapsing–remitting; analysis of variance; ANOVA; FDR; sensorimotor control; FLAIR; corpus callosum; false discovery rate; EDSS; TLV; CC; electroencephalography; LrF; inter-hemispheric coherence indices; total lesion volume; EEG; MS; multiple sclerosis; regions of interest; structural magnetic resonance imaging; lesion relative fraction; ROI; fluid attenuated inversion recovery; maximum voluntary contraction; IHCoh; MVC; inter-hemispheric coherence
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.01.039

Highlights • Corpus callosum (CC) and inter-hemispheric connectivity are compromised early in the course of MS. • Structural MRI and EEG can be used to assess such an early imbalance. • Higher coherence in α band at rest involved sensorimotor sections of corpus callosum. • Inter-hemispheric connectivity displayed a hand-dominance dependence only in α band.