Balancing the interplay of histone deacetylases and non-coding genomes: a step closer to understand the landscape of cancer treatment

Histone deacetylase (HDAC) inhibitors have enormous therapeutic potential as effective epigenetic regulators, and now with the focus on the selective HDAC6 inhibitor in ongoing clinical trials, more advantages over other non-selective pan-HDAC inhibitors are foreseeable. As it is of paramount import...

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Bibliographic Details
Published inBMC medical genomics Vol. 16; no. 1; p. 295
Main Authors Pu, Jingjing, Liu, Ting, Sharma, Amit, Schmidt-Wolf, Ingo G H
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 17.11.2023
BioMed Central
BMC
Subjects
Analysis
Cancer
Cancer therapies
Care and treatment
Clinical trials
Epigenetics
Gene expression
Genomes
Health aspects
Histone deacetylase
Histone Deacetylase 6
Histone Deacetylase Inhibitors - pharmacology
Histone Deacetylase Inhibitors - therapeutic use
Histone deacetylases
Histone Deacetylases - genetics
Histone Deacetylases - metabolism
Histones
Humans
MicroRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Multiple myeloma
Multiple Myeloma - drug therapy
Multiple Myeloma - genetics
Non-coding genome
Oncology
Germany
Epigenetics
Histone deacetylases
Non-coding genome
Cancer
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Summary:Histone deacetylase (HDAC) inhibitors have enormous therapeutic potential as effective epigenetic regulators, and now with the focus on the selective HDAC6 inhibitor in ongoing clinical trials, more advantages over other non-selective pan-HDAC inhibitors are foreseeable. As it is of paramount importance to understand the complex regulatory web of mutual interactions involving epigenetic machinery and non-coding genome in regulating gene expression, herein, we investigated the intriguing interactions between HDAC6-induced lncRNA (LINC00152) and its possible sponge miRNA (hsa-miR-499a-5p) in multiple myeloma.
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ObjectType-Correspondence-1
ISSN:1755-8794
1755-8794
DOI:10.1186/s12920-023-01724-3