Analgesic efficacy and safety of an intraoral lidocaine patch

The effectiveness of intraoral II-docaine patches was tested by asking participants to rate the pain experienced after insertions of a 25-gauge needle. Needlesticks were performed at baseline and at various time points after patch placement. Each needlestick included contact with the periosteum. Lid...

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Bibliographic Details
Published inThe Journal of the American Dental Association (1939) Vol. 127; no. 11; p. 1626
Main Authors Hersh, E V, Houpt, M I, Cooper, S A, Feldman, R S, Wolff, M S, Levin, L M
Format Journal Article
LanguageEnglish
Published England 01.11.1996
Subjects
Administration, Topical
Adolescent
Adult
Aged
Analysis of Variance
Anesthesia, Dental - methods
Anesthesia, Local - methods
Anesthetics, Local - administration & dosage
Chi-Square Distribution
Double-Blind Method
Female
Humans
Injections - adverse effects
Lidocaine - administration & dosage
Male
Middle Aged
Mouth Mucosa
Needles - adverse effects
Pain - etiology
Pain - prevention & control
Pain Measurement
Preanesthetic Medication - methods
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Summary:The effectiveness of intraoral II-docaine patches was tested by asking participants to rate the pain experienced after insertions of a 25-gauge needle. Needlesticks were performed at baseline and at various time points after patch placement. Each needlestick included contact with the periosteum. Lidocaine patches achieved significantly better analgesia than the placebo within 2.5 to five minutes after placement. Drug-related side effects were minimal and venous blood levels of lidocaine were low, averaging 10 to 14 times less than those achieved with a typical injection of lidocaine plus epinephrine. The authors conclude that the lidocaine patches used in this study are effective and safe in reducing needle insertion pain in adults.
ISSN:0002-8177
DOI:10.14219/jada.archive.1996.0098