Phenotyping the obesities: reality or utopia?

In this thematic issue on phenotyping the obesities, prominent international experts offer an insightful and comprehensive collection of articles covering the current knowledge in the field. In order to actually capture all the polyhedral determinants of the diverse types of obesity, the granularity...

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Bibliographic Details
Published inReviews in endocrine & metabolic disorders Vol. 24; no. 5; pp. 767 - 773
Main Authors Portincasa, Piero, Frühbeck, Gema
Format Journal Article
LanguageEnglish
Published New York Springer US 01.10.2023
Springer
Springer Nature B.V
Subjects
Care and treatment
Development and progression
Diabetes
Endocrinology
Humans
Internal Medicine
Medicine
Medicine & Public Health
Obesity
Obesity - diagnosis
Phenotyping
Precision medicine
Type 2 diabetes
Utopias
Obesity
Heterogeneity
Phenotypes
Patient stratification
Comorbidities
Clustering
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Summary:In this thematic issue on phenotyping the obesities, prominent international experts offer an insightful and comprehensive collection of articles covering the current knowledge in the field. In order to actually capture all the polyhedral determinants of the diverse types of obesity, the granularity of the phenotypic information acquired must be expanded in the context of a personalized approach. Whilst the use of precision medicine has been successfully implemented in areas like cancer and other diseases, health care providers are more reluctant to embrace detailed phenotyping to guide diagnosis, treatment and prevention in obesity. Given its multiple complex layers, phenotyping necessarily needs to go beyond the multi-omics approach and incorporate all the diverse spheres that conform the reality of people living with obesity. Potential barriers, difficulties, roadblocks and opportunities together with their interaction in a syndemic context are analyzed. Plausible lacunae are also highlighted in addition to pointing to the need of redefining new conceptual frameworks. Therefore, this extraordinary collection of state-ofthe-art reviews provides useful information to both experienced clinicians and trainees as well as academics to steer clinical practice and research in the management of people living with obesity irrespective of practice setting or career stage.
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ISSN:1389-9155
1573-2606
1573-2606
DOI:10.1007/s11154-023-09829-x