Comparative interactomics: comparing apples and pears?

• Published in: Trends in biotechnology (Regular ed.) Vol. 25; no. 10; pp. 448 - 454
• Main Authors: Kiemer, Lars, Cesareni, Gianni
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.10.2007; Elsevier Science; Elsevier Limited
• Subjects: Animals; Biological and medical sciences; Biotechnology; Evolution, Molecular; Experiments; Fundamental and applied biological sciences. Psychology; Gene Expression - physiology; General aspects; Genomes; Genomics; Humans; Internal Medicine; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects); Models, Biological; Molecular biology; Organisms; Plants; Protein Interaction Mapping - methods; Proteins; Proteins - metabolism; Signal Transduction - physiology; Species Specificity; Studies; Yeast; Molecular interaction; Review; Interactome; Comparative study; Protein; Interactomics
• ISSN: 0167-7799; 1879-3096
• DOI: 10.1016/j.tibtech.2007.08.002

The study of the complex web of interactions that link biological molecules in a cell is the subject of interactomics – currently one of the fastest moving fields in molecular biology. The recent completion of high-throughput studies to investigate systematically all the possible interactions in a variety of model organisms has provided unique opportunities to compare interaction networks and ask questions about their conservation during evolution. It is expected that this approach will yield a scientific return as rich as that obtained in the past decade from comparing genomes and proteomes from different organisms.