Asymmetric adhesive SIS-based wound dressings for therapeutically targeting wound repair

• Published in: Journal of nanobiotechnology Vol. 22; no. 1; p. 34
• Main Authors: Yao, Wende, Song, Zelong, Ma, Xiaodong, Huang, Yiqian, Zhang, Xueying, Li, Yunhuan, Wei, Pengfei, Zhang, Julei, Xiong, Chenlu, Yang, Sihan, Xu, Yujian, Jing, Wei, Zhao, Bo, Zhang, Xuesong, Han, Yan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.01.2024; BioMed Central; BMC
• Subjects: Acids; Adhesion; Adhesive strength; Adhesives; Adhesives - pharmacology; Angiogenesis; Animal models; Animals; Asymmetric composite; Asymmetry; Bacterial infections; Bandages; Biopsy; Bursting strength; Care and treatment; Cell culture; Cell growth; Cell viability; Comparative analysis; Composite materials; Extracellular matrix; Fibroblasts; Health aspects; Humans; Injuries; Medical dressings; Medical research; Nanoparticles; Polymerization; Prevention; Rats; Regeneration (physiology); Risk factors; Shear strength; SIS; Skin; Skin injuries; Small intestine; Swine; Tissue engineering; Tissue regeneration; Tissues; Vascularization; Wound dressing; Wound Healing; Wounds and injuries; China; Beijing China; United States > US; Wound dressing; SIS; Tissue regeneration; Asymmetric composite; Vascularization
• ISSN: 1477-3155; 1477-3155
• DOI: 10.1186/s12951-024-02294-x

Severe tissue injuries pose a significant risk to human health. Conventional wound dressings fall short in achieving effective tissue regeneration, resulting in suboptimal postoperative healing outcomes. In this study, an asymmetric adhesive wound dressing (marked as SIS/PAA/LAP) was developed, originating from acrylate acid (AA) solution with laponite (LAP) nanoparticles polymerization and photo-crosslinked on the decellularized extracellular matrix small intestinal submucosa (SIS) patch. Extensive studies demonstrated that the SIS/PAA/LAP exhibited higher tissue adhesion strength (~ 33 kPa) and burst strength (~ 22 kPa) compared to conventional wound dressings like Tegaderm and tissue adhesive products. Importantly, it maintained favorable cell viability and demonstrated robust angiogenic capacity. In animal models of full-thickness skin injuries in rats and skin injuries in Bama miniature pigs, the SIS/PAA/LAP could be precisely applied to wound sites. By accelerating the formation of tissue vascularization, it displayed superior tissue repair outcomes. This asymmetrically adhesive SIS-based patch would hold promising applications in the field of wound dressings.