Relationship between sulfaguanidine resistance and increased cellulose production in Acetobacter xylinum BPR3001E

The mechanism of the increased cell growth and cellulose production of Acetobacter xylinum subsp. sucrofermentans BPR3001E, a sulfaguanidine (SG)-resistant mutant, was investigated. We found that adding p-aminobenzoic acid (PABA) to cultures of the parent strain, BPR2001, led to increased levels of...

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Published inBioscience, biotechnology, and biochemistry Vol. 62; no. 6; pp. 1234 - 1236
Main Authors Ishikawa, A. (Bio-Polymer Research Co. Ltd., Kawasaki, Kanagawa (Japan)), Tsuchida, T, Yoshinaga, F
Format Journal Article
LanguageEnglish
Published Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 01.01.1998
Japan Society for Bioscience Biotechnology and Agrochemistry
Subjects
ACETOBACTER
Acetobacter xylinum sucrofermentans
ACIDE BENZOIQUE
ACIDO BENZOICO
ATP
BENZOIC ACID
Biological and medical sciences
Biotechnology
CELLULOSE
CELULOSA
Fundamental and applied biological sciences. Psychology
GUANIDINA
GUANIDINE
GUANIDINES
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
p-aminobenzoic acid
sulfaguanidine
Acetobacteraceae
Resistance
Acetobacter xylinum
High energy phosphate
Correlation analysis
Cellulose
Production
Microorganism culture
Bacteria
Metabolism
Sulfaguanidine
Adenine nucleotide
cellulose
ATP
sulfaguanidine
p-aminobenzoic acid
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Summary:The mechanism of the increased cell growth and cellulose production of Acetobacter xylinum subsp. sucrofermentans BPR3001E, a sulfaguanidine (SG)-resistant mutant, was investigated. We found that adding p-aminobenzoic acid (PABA) to cultures of the parent strain, BPR2001, led to increased levels of intracellular adenosine-related purine compounds and increased cellulose production. Furthermore, adding ATP increased the cellulose production by permeabilized BPR2001 cells. ON the other hand, the intracellular levels of PABA and adenosine-related purine compounds in BPR3001E cells were higher than those in BPR2001 cells. These results suggest that SG resistance increases enhance cellulose production through increased levels of intracellular high-energy compounds caused by increased PABA biosynthesis, reflecting the promoted supply of cellulose precursors
Bibliography:F60
1999000961
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ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.62.1234